Retinoic acid acts as a selective human IgA switch factor

Goo Young Seo, Young Saeng Jang, Jini Kim, Jongseon Choe, Hye Ju Han, Jeong Min Lee, Seong Ho Kang, Ki Jong Rhee, Seok Rae Park, Woan Sub Kim, Pyeung Hyeun Kim

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Abstract

Retinoic acid (RA) is known to have several functions that lead to a potent mucosal IgA response. Nevertheless, its exact role in human IgA synthesis has yet to be elucidated. Thus, we investigated the role of RA in promoting IgA isotype switching in human B cells. We found that RA increased IgA production and the expression of germ-line IgA1 and IgA2 transcripts (GLTα1 and GLTα2). This induction occurred alongside an increase in the frequency of IgA1-secreting B cell clones, as assessed by limiting dilution analysis. Under the same conditions, RA did not increase IgM and IgG production. Am80, an agonist of RA receptor α (RARα), increased IgA production. In addition, RA activity was abrogated by LE540, an antagonist of RAR, suggesting that the RAR pathway is involved in RA-induced IgA production. Taken together, these results indicate that RA induces IgA isotype switching mainly through RARα in human B cells.

Original languageEnglish
Pages (from-to)923-929
Number of pages7
JournalHuman Immunology
Volume75
Issue number8
DOIs
Publication statusPublished - 2014 Aug

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Seo, G. Y., Jang, Y. S., Kim, J., Choe, J., Han, H. J., Lee, J. M., Kang, S. H., Rhee, K. J., Park, S. R., Kim, W. S., & Kim, P. H. (2014). Retinoic acid acts as a selective human IgA switch factor. Human Immunology, 75(8), 923-929. https://doi.org/10.1016/j.humimm.2014.06.021