Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin

A double-blind, randomized-controlled trial

H. Kim, J. Koh, J. Baek, Y. Seo, B. Kim, J. Kim, J. Lee, H. Ryoo, Hyungil Jung

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: All-trans-retinoic acid (RA) and all-trans-retinol (ROL) are not widely used as anti-wrinkle agents due to their irritancy and photo-stability, respectively. Therefore, the safety and photo-stability in the development of RA or ROL derivatives have been an important issue. Aim: To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles. Methods: The clinical study was a prospective, double-blind, randomized, and controlled study with a total of 11 Korean women. At every 4 weeks, the effectiveness was assessed with a global photodamage score, photographs, and image analysis using replicas and visiometers. The dermal distance and intensity was also evaluated using Dermascan C. Results: A statistically significant improvement in facial wrinkles (P<0.05) in eleven volunteers was observed in a clinical trial. The successive application of 0.06% retinyl retinoate cream for 3 months showed decreased depth and area of wrinkles in comparison with 0.075% retinol cream. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for retinyl retinoate cream were 22% higher than that of retinol cream after 12 weeks. A statistically significant increase was observed after 8 and 4 weeks for dermal distance and dermal intensity, respectively (P<0.05). Conclusions: Retinyl retinoate had characteristic features of new anti-aging agents, and effectively improved facial wrinkle conditions.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalSkin Research and Technology
Volume17
Issue number3
DOIs
Publication statusPublished - 2011 Aug 1

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Vitamin A
Vitamins
Randomized Controlled Trials
Skin
Tretinoin
Cosmetics
Volunteers
Clinical Trials
Safety
retinyl retinoate

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, H. ; Koh, J. ; Baek, J. ; Seo, Y. ; Kim, B. ; Kim, J. ; Lee, J. ; Ryoo, H. ; Jung, Hyungil. / Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin : A double-blind, randomized-controlled trial. In: Skin Research and Technology. 2011 ; Vol. 17, No. 3. pp. 380-385.
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Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin : A double-blind, randomized-controlled trial. / Kim, H.; Koh, J.; Baek, J.; Seo, Y.; Kim, B.; Kim, J.; Lee, J.; Ryoo, H.; Jung, Hyungil.

In: Skin Research and Technology, Vol. 17, No. 3, 01.08.2011, p. 380-385.

Research output: Contribution to journalArticle

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T1 - Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin

T2 - A double-blind, randomized-controlled trial

AU - Kim, H.

AU - Koh, J.

AU - Baek, J.

AU - Seo, Y.

AU - Kim, B.

AU - Kim, J.

AU - Lee, J.

AU - Ryoo, H.

AU - Jung, Hyungil

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N2 - Background: All-trans-retinoic acid (RA) and all-trans-retinol (ROL) are not widely used as anti-wrinkle agents due to their irritancy and photo-stability, respectively. Therefore, the safety and photo-stability in the development of RA or ROL derivatives have been an important issue. Aim: To identify the efficacy of retinyl retinoate as an anti-aging agent of cosmetics in treating females over 30 years old with periorbital wrinkles. Methods: The clinical study was a prospective, double-blind, randomized, and controlled study with a total of 11 Korean women. At every 4 weeks, the effectiveness was assessed with a global photodamage score, photographs, and image analysis using replicas and visiometers. The dermal distance and intensity was also evaluated using Dermascan C. Results: A statistically significant improvement in facial wrinkles (P<0.05) in eleven volunteers was observed in a clinical trial. The successive application of 0.06% retinyl retinoate cream for 3 months showed decreased depth and area of wrinkles in comparison with 0.075% retinol cream. The visual wrinkle improvement and the maximum roughness improvement rate (R2) for retinyl retinoate cream were 22% higher than that of retinol cream after 12 weeks. A statistically significant increase was observed after 8 and 4 weeks for dermal distance and dermal intensity, respectively (P<0.05). Conclusions: Retinyl retinoate had characteristic features of new anti-aging agents, and effectively improved facial wrinkle conditions.

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