Retinyl retinoate induces hyaluronan production and less irritation than other retinoids

Jin Eun Kim, Bora Kim, Hyuk Kim, Hyojung Kim, Joo Dong Lee, Hyun Jung Kim, Kang Yell Choi, Seung Hun Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hyaluronan, a non-sulfated glycosaminoglycan, retains water, maintains the extracellular spaces and facilitates the transport of ion solutes and nutrients. Hyaluronan is closely involved in keratinocyte proliferation, migration and differentiation. The synthesis of hyaluronan in vitro can be stimulated by several growth factors, including retinoids, dibutyryl cyclic adenosine monophosphate and peroxisome proliferator-activated receptor-α agonist. In this study, we examined retinyl retinoate (a novel retinol derivative) on hyaluronan expression in primary human keratinocytes and in hairless mouse epidermal skin. Histochemistry using hyaluronan-binding protein revealed that topical retinyl retinoate increased the intensity of hyaluronan staining in murine skin. Moreover, topical retinyl retinoate increased CD44 (hyaluronan receptor) expression. Using reverse transcription polymerase chain reaction, we assessed the expression level of the hyaluronan synthase 2 (HAS2) gene in primary human keratinocytes and in hairless mouse epidermal skin. We found that retinyl retinoate upregulated mouse HAS2 and human HAS2 mRNA. Application of retinyl retinoate induced increasing transepidermal water loss less than retinol, retinoic acid and retinaldehyde. Taken together, we suggest that retinyl retinoate is more effective on hyaluronan production and less of an irritant than other retinoids.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalJournal of Dermatology
Volume37
Issue number5
DOIs
Publication statusPublished - 2010 May

All Science Journal Classification (ASJC) codes

  • Dermatology

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