Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation

Min Su Cho, Jin Kyung Lee, Keumseok Bae, Eun Ae Han, Seong Jae Jang, Wi Ho Ha, Seung Sook Lee, Joan Francesc Barquinero, Wan Tae Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two cases of hematological malignancies were reported in an industrial radiography company over a year, which were reasonably suspected of being consequences of prolonged exposure to ionizing radiation because of the higher incidence than expected in the general population. We analyzed chromosomal aberrations in the peripheral blood lymphocytes from the other workers who had been working under similar circumstances as the patients in the company. Among the subjects tested, 10 workers who belonged to the highest band were followed up periodically for 1.5 years since the first analysis. The aim of this study was to clarify pertinence of translocation analysis to an industrial set-up where chronic exposure was commonly expected. To be a useful tool for a retrospective biodosimetry, the aberrations need to be persistent for a decade or longer. Therefore we calculated the decline rates and half-lives of frequency for both a reciprocal translocation and a dicentric chromosome and compared them. In this study, while the frequency of reciprocal translocations was maintained at the initial level, dicentric chromosomes were decreased to 46.9% (31.0-76.5) of the initial frequency over the follow-up period. Our results support the long-term stability of reciprocal translocation through the cell cycle and validate the usefulness of translocation analysis as a retrospective biodosimetry for cases of occupational exposure.

Original languageEnglish
Pages (from-to)709-716
Number of pages8
JournalJournal of Radiation Research
Volume56
Issue number4
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Ionizing Radiation
ionizing radiation
Chromosomes
chromosomes
aberration
Hematologic Neoplasms
Occupational Exposure
cells
Radiography
Chromosome Aberrations
Cell Cycle
lymphocytes
radiography
Lymphocytes
half life
blood
Incidence
incidence
Population
cycles

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Cho, Min Su ; Lee, Jin Kyung ; Bae, Keumseok ; Han, Eun Ae ; Jang, Seong Jae ; Ha, Wi Ho ; Lee, Seung Sook ; Barquinero, Joan Francesc ; Kim, Wan Tae. / Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation. In: Journal of Radiation Research. 2015 ; Vol. 56, No. 4. pp. 709-716.
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Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation. / Cho, Min Su; Lee, Jin Kyung; Bae, Keumseok; Han, Eun Ae; Jang, Seong Jae; Ha, Wi Ho; Lee, Seung Sook; Barquinero, Joan Francesc; Kim, Wan Tae.

In: Journal of Radiation Research, Vol. 56, No. 4, 01.01.2015, p. 709-716.

Research output: Contribution to journalArticle

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