Retrospective review of 19 patients with lentigo maligna melanoma

Won Jin Hong, Hong Sun Jang, Sang Hee Lee, Sang Eun Lee, Kee Yang Chung, MiRyung Roh

Research output: Contribution to journalReview article

Abstract

Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4 - 15S5 of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003 ~ 2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickncss (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage 111; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide cxcision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-A therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mcbutatc. Two patients had BRAF V600E mutation; I, NRAS (J12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients.

Original languageEnglish
Pages (from-to)769-775
Number of pages7
JournalKorean Journal of Dermatology
Volume54
Issue number10
Publication statusPublished - 2016 Jan 1

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Hutchinson's Melanotic Freckle
Melanoma
Mutation
Mohs Surgery

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Hong, W. J., Jang, H. S., Lee, S. H., Lee, S. E., Chung, K. Y., & Roh, M. (2016). Retrospective review of 19 patients with lentigo maligna melanoma. Korean Journal of Dermatology, 54(10), 769-775.
Hong, Won Jin ; Jang, Hong Sun ; Lee, Sang Hee ; Lee, Sang Eun ; Chung, Kee Yang ; Roh, MiRyung. / Retrospective review of 19 patients with lentigo maligna melanoma. In: Korean Journal of Dermatology. 2016 ; Vol. 54, No. 10. pp. 769-775.
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title = "Retrospective review of 19 patients with lentigo maligna melanoma",
abstract = "Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4 - 15S5 of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003 ~ 2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickncss (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4{\%}), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage 111; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide cxcision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-A therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mcbutatc. Two patients had BRAF V600E mutation; I, NRAS (J12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients.",
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Hong, WJ, Jang, HS, Lee, SH, Lee, SE, Chung, KY & Roh, M 2016, 'Retrospective review of 19 patients with lentigo maligna melanoma', Korean Journal of Dermatology, vol. 54, no. 10, pp. 769-775.

Retrospective review of 19 patients with lentigo maligna melanoma. / Hong, Won Jin; Jang, Hong Sun; Lee, Sang Hee; Lee, Sang Eun; Chung, Kee Yang; Roh, MiRyung.

In: Korean Journal of Dermatology, Vol. 54, No. 10, 01.01.2016, p. 769-775.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Retrospective review of 19 patients with lentigo maligna melanoma

AU - Hong, Won Jin

AU - Jang, Hong Sun

AU - Lee, Sang Hee

AU - Lee, Sang Eun

AU - Chung, Kee Yang

AU - Roh, MiRyung

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4 - 15S5 of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003 ~ 2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickncss (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage 111; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide cxcision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-A therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mcbutatc. Two patients had BRAF V600E mutation; I, NRAS (J12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients.

AB - Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4 - 15S5 of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003 ~ 2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickncss (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage 111; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide cxcision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-A therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mcbutatc. Two patients had BRAF V600E mutation; I, NRAS (J12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients.

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Hong WJ, Jang HS, Lee SH, Lee SE, Chung KY, Roh M. Retrospective review of 19 patients with lentigo maligna melanoma. Korean Journal of Dermatology. 2016 Jan 1;54(10):769-775.