Revealing the roles of keratin 8/18-associated signaling proteins involved in the development of hepatocellular carcinoma

Younglan Lim; Nam On Ku

doi:10.3390/ijms22126401

Revealing the roles of keratin 8/18-associated signaling proteins involved in the development of hepatocellular carcinoma

Younglan Lim, Nam On Ku

Interdisciplinary Program of Integrated OMICS for Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.

Original language	English
Article number	6401
Journal	International journal of molecular sciences
Volume	22
Issue number	12
DOIs	https://doi.org/10.3390/ijms22126401
Publication status	Published - 2021 Jun 2

Bibliographical note

Funding Information:
Funding: This work was supported by the Korean Ministry of Education, Science, and Technology, grant 2018R1D1A1A02086060, and the Yonsei University Research Fund 2018-22-0072 (to N-O.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Revealing the roles of keratin 8/18-associated signaling proteins involved in the development of hepatocellular carcinoma",

abstract = "Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.",

author = "Younglan Lim and Ku, {Nam On}",

note = "Funding Information: Funding: This work was supported by the Korean Ministry of Education, Science, and Technology, grant 2018R1D1A1A02086060, and the Yonsei University Research Fund 2018-22-0072 (to N-O.K.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Lim, Younglan

AU - Ku, Nam On

N1 - Funding Information: Funding: This work was supported by the Korean Ministry of Education, Science, and Technology, grant 2018R1D1A1A02086060, and the Yonsei University Research Fund 2018-22-0072 (to N-O.K.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/2

Y1 - 2021/6/2

N2 - Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.

AB - Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.

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Revealing the roles of keratin 8/18-associated signaling proteins involved in the development of hepatocellular carcinoma

Abstract

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