Revealing the roles of keratin 8/18-associated signaling proteins involved in the development of hepatocellular carcinoma

Younglan Lim, Nam On Ku

Research output: Contribution to journalReview articlepeer-review

Abstract

Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.

Original languageEnglish
Article number6401
JournalInternational journal of molecular sciences
Volume22
Issue number12
DOIs
Publication statusPublished - 2021 Jun 2

Bibliographical note

Funding Information:
Funding: This work was supported by the Korean Ministry of Education, Science, and Technology, grant 2018R1D1A1A02086060, and the Yonsei University Research Fund 2018-22-0072 (to N-O.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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