Abstract
Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
| Original language | English |
|---|---|
| Pages (from-to) | 553-559 |
| Number of pages | 7 |
| Journal | Ophthalmology |
| Volume | 120 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma. / Lee, Eun Ji; Kim, Tae Woo; Weinreb, Robert N.; Kim, Hyunjoong.
In: Ophthalmology, Vol. 120, No. 3, 01.03.2013, p. 553-559.Research output: Contribution to journal › Article
TY - JOUR
T1 - Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma
AU - Lee, Eun Ji
AU - Kim, Tae Woo
AU - Weinreb, Robert N.
AU - Kim, Hyunjoong
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
AB - Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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UR - http://www.scopus.com/inward/citedby.url?scp=84875211548&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2012.08.047
DO - 10.1016/j.ophtha.2012.08.047
M3 - Article
C2 - 23218823
AN - SCOPUS:84875211548
VL - 120
SP - 553
EP - 559
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 3
ER -