Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma

Eun Ji Lee, Tae Woo Kim, Robert N. Weinreb, Hyunjoong Kim

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalOphthalmology
Volume120
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

Fingerprint

Open Angle Glaucoma
Intraocular Pressure
Optic Disk
Optical Coherence Tomography
Bruch Membrane
Disclosure
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Lee, Eun Ji ; Kim, Tae Woo ; Weinreb, Robert N. ; Kim, Hyunjoong. / Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma. In: Ophthalmology. 2013 ; Vol. 120, No. 3. pp. 553-559.
@article{a4193dbbe3cb42f5a5aa48ecbb76afc5,
title = "Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma",
abstract = "Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20{\%} compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.",
author = "Lee, {Eun Ji} and Kim, {Tae Woo} and Weinreb, {Robert N.} and Hyunjoong Kim",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.ophtha.2012.08.047",
language = "English",
volume = "120",
pages = "553--559",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "3",

}

Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma. / Lee, Eun Ji; Kim, Tae Woo; Weinreb, Robert N.; Kim, Hyunjoong.

In: Ophthalmology, Vol. 120, No. 3, 01.03.2013, p. 553-559.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma

AU - Lee, Eun Ji

AU - Kim, Tae Woo

AU - Weinreb, Robert N.

AU - Kim, Hyunjoong

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - Purpose: To compare the change in lamina cribrosa (LC) displacement in response to intraocular pressure (IOP) lowering in patients with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: One hundred eyes of 100 patients with OAG in whom IOP at the follow-up examination had decreased by at least 20% compared with the baseline IOP. Methods: Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging SD-OCT. Approximately 65 B-scans covering the optic discs were obtained before and 3 to 6 months after lowering IOP. The baseline and follow-up LC depths (the distance from the Bruch's membrane opening plane to the level of the anterior LC surface) were measured in B-scan images from each eye. Main Outcome Measures: The mean and maximum amount of reductions in LC depth measured in the 7 selected B-scan images. Results: Intraocular pressure decreased from 21.2±9.1 to 10.5±2.6 mmHg. The percent of IOP reduction was significantly related to the untreated IOP (P < 0.001). There was a significant decrease in the LC depth at the follow-up examination compared with the baseline value (P < 0.001). The magnitude of LC depth reduction was significantly associated with younger age, higher untreated IOP, higher baseline IOP, and greater percent of IOP reduction (all P < 0.02). Conclusions: Reversal of the LC displacement was observed after IOP-lowering treatment in OAG. The degree of LC displacement reversal was related to the amount of IOP lowering. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

UR - http://www.scopus.com/inward/record.url?scp=84875211548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875211548&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2012.08.047

DO - 10.1016/j.ophtha.2012.08.047

M3 - Article

C2 - 23218823

AN - SCOPUS:84875211548

VL - 120

SP - 553

EP - 559

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 3

ER -