Revisiting the ventral medial nucleus of the hypothalamus: The roles of SF-1 neurons in energy homeostasis

Yun Hee Choi, Teppei Fujikawa, Jiwon Lee, Anne Reuter, Ki Woo Kim

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.

Original languageEnglish
Article numberArticle 71
JournalFrontiers in Neuroscience
Issue number7 MAY
DOIs
Publication statusPublished - 2013 Jun 17

Fingerprint

Steroidogenic Factor 1
Middle Hypothalamus
Homeostasis
Neurons
Glucose
Genetic Models
Energy Metabolism
Public Health
Obesity
Eating

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

@article{300dc80a7d454710b150d032f3ac623f,
title = "Revisiting the ventral medial nucleus of the hypothalamus: The roles of SF-1 neurons in energy homeostasis",
abstract = "Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.",
author = "Choi, {Yun Hee} and Teppei Fujikawa and Jiwon Lee and Anne Reuter and Kim, {Ki Woo}",
year = "2013",
month = "6",
day = "17",
doi = "10.3389/fnins.2013.00071",
language = "English",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "7 MAY",

}

Revisiting the ventral medial nucleus of the hypothalamus : The roles of SF-1 neurons in energy homeostasis. / Choi, Yun Hee; Fujikawa, Teppei; Lee, Jiwon; Reuter, Anne; Kim, Ki Woo.

In: Frontiers in Neuroscience, No. 7 MAY, Article 71, 17.06.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Revisiting the ventral medial nucleus of the hypothalamus

T2 - The roles of SF-1 neurons in energy homeostasis

AU - Choi, Yun Hee

AU - Fujikawa, Teppei

AU - Lee, Jiwon

AU - Reuter, Anne

AU - Kim, Ki Woo

PY - 2013/6/17

Y1 - 2013/6/17

N2 - Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.

AB - Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=84878819433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878819433&partnerID=8YFLogxK

U2 - 10.3389/fnins.2013.00071

DO - 10.3389/fnins.2013.00071

M3 - Article

C2 - 23675313

AN - SCOPUS:84878819433

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - 7 MAY

M1 - Article 71

ER -