Revisiting the Warburg Effect: Diet-Based Strategies for Cancer Prevention

Quangdon Tran, Hyunji Lee, Chaeyeong Kim, Gyeyeong Kong, Nayoung Gong, So Hee Kwon, Jisoo Park, Seon Hwan Kim, Jongsun Park

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic glycolysis; this phenomenon is described as the Warburg effect. However, whether the Warburg effect is caused by genetic dysregulation in cancer or is the cause of cancer remains unknown. The exact reasons and physiology of this abnormal metabolism are unclear; therefore, many researchers have attempted to reduce malignant cell growth in tumors in preclinical and clinical studies. Anticancer strategies based on the Warburg effect have involved the use of drug compounds and dietary changes. We recently reviewed applications of the Warburg effect to understand the benefits of this unusual cancer-related metabolism. In the current article, we summarize diet strategies for cancer treatment based on the Warburg effect.

Original languageEnglish
Article number8105735
JournalBioMed Research International
Volume2020
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic glycolysis; this phenomenon is described as the Warburg effect. However, whether the Warburg effect is caused by genetic dysregulation in cancer or is the cause of cancer remains unknown. The exact reasons and physiology of this abnormal metabolism are unclear; therefore, many researchers have attempted to reduce malignant cell growth in tumors in preclinical and clinical studies. Anticancer strategies based on the Warburg effect have involved the use of drug compounds and dietary changes. We recently reviewed applications of the Warburg effect to understand the benefits of this unusual cancer-related metabolism. In the current article, we summarize diet strategies for cancer treatment based on the Warburg effect. National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) NRF-2020R1F1A1049801 Chungnam National University

Publisher Copyright:
© 2020 Quangdon Tran et al.

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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