RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction

In Duk Jung, Hye Young Kim, Jin Wook Park, Chang Min Lee, Kyung Tae Noh, Hyun Kyu Kang, Deok Rim Heo, Su Jung Lee, Kwang Hee Son, Hee ju Park, Sung Jae Shin, Jong Hwan Park, Seung Wook Ryu, Yeong Min Park

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13 Citations (Scopus)

Abstract

In asthma, T helper 2 (T H2)-type cytokines such as interleukin (IL)-4, IL-5, and IL-13 are produced by activated CD4 + T cells. Dendritic cells played an important role in determining the fate of naïve T cells into either T H1 or T H2 cells. We determined whether RG-II regulates the T H1/T H2 immune response by using an ovalbumin-induced murine model of asthma. RG-II reduced IL-4 production but increased interferon-gamma production, and inhibited GATA-3 gene expression. RG-II also inhibited asthmatic reactions including an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration in lung tissues, airway luminal narrowing, and airway hyperresponsiveness. This study provides evidence that RG-II plays a critical role in ameliorating the pathogenic process of asthmatic inflammation in mice. These findings provide new insights into the immunotherapeutic role of RG-II in terms of its effects in a murine model of asthma.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalBMB reports
Volume45
Issue number2
DOIs
Publication statusPublished - 2012 Feb

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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    Jung, I. D., Kim, H. Y., Park, J. W., Lee, C. M., Noh, K. T., Kang, H. K., Heo, D. R., Lee, S. J., Son, K. H., Park, H. J., Shin, S. J., Park, J. H., Ryu, S. W., & Park, Y. M. (2012). RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction. BMB reports, 45(2), 79-84. https://doi.org/10.5483/BMBRep.2012.45.2.79