Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor

Jae Seung Moon, Diane Da Hyun Lee, YongBeom Park, Sang Won Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.

Original languageEnglish
Pages (from-to)2771-2779
Number of pages9
JournalClinical Rheumatology
Volume37
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1

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Antineutrophil Cytoplasmic Antibodies
Rheumatoid Factor
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Vasculitis
Skin Manifestations
Rheumatoid Arthritis
Granulomatosis with Polyangiitis
Recurrence
Eye Manifestations
Survival Rate
Microscopic Polyangiitis
Kaplan-Meier Estimate
Survival Analysis
Peroxidase
Medical Records
Multivariate Analysis
Logistic Models
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

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title = "Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor",
abstract = "We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9{\%}) were classified as microscopic polyangiitis (MPA), 29 (22.7{\%}) as granulomatosis with polyangiitis (GPA) and 30 (23.4{\%}) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1{\%} in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1{\%} in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.",
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Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor. / Moon, Jae Seung; Lee, Diane Da Hyun; Park, YongBeom; Lee, Sang Won.

In: Clinical Rheumatology, Vol. 37, No. 10, 01.10.2018, p. 2771-2779.

Research output: Contribution to journalArticle

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AU - Lee, Diane Da Hyun

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