Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives

Sung Gon Lim, Jun Hee Lee, Choong Woon Moon, Jun Bae Hong, Chul Ho Jun

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Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.

Original languageEnglish
Pages (from-to)2759-2761
Number of pages3
JournalOrganic Letters
Issue number15
Publication statusPublished - 2003 Jul 24


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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