Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives

Sung Gon Lim, Jun Hee Lee, Choong Woon Moon, Jun Bae Hong, Chul Ho Jun

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.

Original languageEnglish
Pages (from-to)2759-2761
Number of pages3
JournalOrganic Letters
Volume5
Issue number15
DOIs
Publication statusPublished - 2003 Jul 24

Fingerprint

Alkenylation
Alkynes
alkynes
Ketones
ketones
Derivatives
synthesis
catalysts
Catalysts
ketimine
isoquinoline

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives. / Lim, Sung Gon; Lee, Jun Hee; Moon, Choong Woon; Hong, Jun Bae; Jun, Chul Ho.

In: Organic Letters, Vol. 5, No. 15, 24.07.2003, p. 2759-2761.

Research output: Contribution to journalArticle

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AU - Lim, Sung Gon

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AU - Hong, Jun Bae

AU - Jun, Chul Ho

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N2 - Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.

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