Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives

Sung Gon Lim, Jun Hee Lee, Choong Woon Moon, Jun Bae Hong, Chul-Ho Jun

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.

Original languageEnglish
Pages (from-to)2759-2761
Number of pages3
JournalOrganic Letters
Volume5
Issue number15
DOIs
Publication statusPublished - 2003 Jul 24

Fingerprint

Alkenylation
Alkynes
alkynes
Ketones
ketones
Derivatives
synthesis
catalysts
Catalysts
ketimine
isoquinoline

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives. / Lim, Sung Gon; Lee, Jun Hee; Moon, Choong Woon; Hong, Jun Bae; Jun, Chul-Ho.

In: Organic Letters, Vol. 5, No. 15, 24.07.2003, p. 2759-2761.

Research output: Contribution to journalArticle

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AU - Moon, Choong Woon

AU - Hong, Jun Bae

AU - Jun, Chul-Ho

PY - 2003/7/24

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N2 - Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.

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