Rh(I)-catalyzed solvent-free ortho-alkylation of aromatic imines under microwave irradiation

Giang Vo-Thanh, Hind Lahrache, André Loupy, In Jung Kim, Duck Ho Chang, Chul Ho Jun

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30 Citations (Scopus)

Abstract

The synthesis of ortho-alkylated ketones through a chelation-assisted Rh (I) catalyzed ortho-alkylation reaction of aromatic imines under microwave activated solvent-free conditions in monomode reactors was performed. These conditions have been also applied to hydroacylation and ortho-alkylation reactions with aldimines.

Original languageEnglish
Pages (from-to)5539-5543
Number of pages5
JournalTetrahedron
Volume60
Issue number26
DOIs
Publication statusPublished - 2004 Jun 21

Bibliographical note

Funding Information:
This work was supported in part by the National Research Laboratory Program (NRL, 2000-N-NL-010C-271) administered by the Ministry of Science and Technology and CBMH. We thank sincerely Dr Renée Paugam (Paris-South University, Laboratoire des Carbocycles) for skilled assistance in theoretical calculations section of the polarity of the transition state.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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