The synthesis of ortho-alkylated ketones through a chelation-assisted Rh (I) catalyzed ortho-alkylation reaction of aromatic imines under microwave activated solvent-free conditions in monomode reactors was performed. These conditions have been also applied to hydroacylation and ortho-alkylation reactions with aldimines.
Bibliographical noteFunding Information:
This work was supported in part by the National Research Laboratory Program (NRL, 2000-N-NL-010C-271) administered by the Ministry of Science and Technology and CBMH. We thank sincerely Dr Renée Paugam (Paris-South University, Laboratoire des Carbocycles) for skilled assistance in theoretical calculations section of the polarity of the transition state.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry