Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing

Seung Hee Baek, Young Chang Kwon, Hyangkyu Lee, Kwang Min Choe

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume394
Issue number3
DOIs
Publication statusPublished - 2010 Apr 9

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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