A hydroxamate-based chemosensor, which responds fluorescently and colorimetrically to FeIII in micromolar ranges, has been developed. The rhodamine hydroxamate probe is prepared in two steps from rhodamine B base. The biomimetic hydroxamate binding site is attached to the rhodamine fluorophore to recognize FeIII selectively over other biologically important metal ions.
Bibliographical noteFunding Information:
This work was supported by the Center for Bioactive Molecular Hybrids (MOST/KOSEF). S.B. thanks BK 21 program (KRF).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry