Rhodium(I)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C-H bond activation of N-methylamine

Eun Ae Jo, Ji Hyun Lee, Chul Ho Jun

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28 Citations (Scopus)

Abstract

The hydroacylation of methanol with alkenes was developed using a catalytic system consisting of Rh(i), 2-amino-4-picoline and benzoic acid; the reaction is speculated to occur by the initial N-methylation of 2-amino-4-picoline with methanol, and the subsequent dehydrogenation of the resulting N-methylamine, followed by double chelation-assisted hydroimination of alkene with the imine to give dialkyl ketones after hydrolysis.

Original languageEnglish
Pages (from-to)5779-5781
Number of pages3
JournalChemical Communications
Issue number44
DOIs
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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