Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells

Eun Ju Jeong, Sang Hyun Sung, Jinwoong Kim, Seung Hyun Kim, Young Choong Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The methanolic extract of Rhus verniciflua Stokes (RVS-T) and its fractions (RVS-H, RVS-C, RVS-E and RVS-B) showed significant neuroprotective activity against glutamate-induced toxicity in primary cultures of rat cortical cells. RVS-B, which showed the most potent neuroprotective activity, was further fractionated to yield RVS-B5. Treatment of cortical cells with the RVS-T, RVS-B and RVS-B5 reduced the cellular ROS level and restored the reduced activities of glutathione reductase and SOD induced by glutamate. Although, the activity of glutathione peroxidase was not virtually changed by glutamate, RVS-B5 increased the glutathione peroxidase activity. In addition, these three tested fractions significantly restored the content of GSH which was decreased by glutamate insult in our cultures. Taken together, it could be postulated that RVS extract, in particular its fraction RVS-B5, protected neuronal cells against glutamate-induced neurotoxicity through acting on the antioxidative defense system.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalNatural Product Sciences
Volume14
Issue number3
Publication statusPublished - 2008 Sep

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells'. Together they form a unique fingerprint.

  • Cite this