Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells

Eun Ju Jeong, Sang Hyun Sung, Jinwoong Kim, Seung Hyun Kim, Young Choong Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The methanolic extract of Rhus verniciflua Stokes (RVS-T) and its fractions (RVS-H, RVS-C, RVS-E and RVS-B) showed significant neuroprotective activity against glutamate-induced toxicity in primary cultures of rat cortical cells. RVS-B, which showed the most potent neuroprotective activity, was further fractionated to yield RVS-B5. Treatment of cortical cells with the RVS-T, RVS-B and RVS-B5 reduced the cellular ROS level and restored the reduced activities of glutathione reductase and SOD induced by glutamate. Although, the activity of glutathione peroxidase was not virtually changed by glutamate, RVS-B5 increased the glutathione peroxidase activity. In addition, these three tested fractions significantly restored the content of GSH which was decreased by glutamate insult in our cultures. Taken together, it could be postulated that RVS extract, in particular its fraction RVS-B5, protected neuronal cells against glutamate-induced neurotoxicity through acting on the antioxidative defense system.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalNatural Product Sciences
Volume14
Issue number3
Publication statusPublished - 2008 Sep 1

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Rhus
Rats
Glutamic Acid
Glutathione Peroxidase
Glutathione Reductase
Glutathione
Toxicity
Cells

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry

Cite this

Jeong, Eun Ju ; Sung, Sang Hyun ; Kim, Jinwoong ; Kim, Seung Hyun ; Kim, Young Choong. / Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In: Natural Product Sciences. 2008 ; Vol. 14, No. 3. pp. 156-160.
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Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells. / Jeong, Eun Ju; Sung, Sang Hyun; Kim, Jinwoong; Kim, Seung Hyun; Kim, Young Choong.

In: Natural Product Sciences, Vol. 14, No. 3, 01.09.2008, p. 156-160.

Research output: Contribution to journalArticle

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