Rifabutin is active against mycobacterium abscessus in mice

Thomas Dick, Sung Jae Shin, Won Jung Koh, Véronique Dartois, Martin Gengenbacher

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.

Original languageEnglish
Article numbere01943
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number2
DOIs
Publication statusPublished - 2020 Jan 27

Bibliographical note

Funding Information:
Research reported in this publication is supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award numbers R01AI132374 and U19AI142731 to T.D. and R21AI145396 to M.G. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2020 American Society for Microbiology. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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