Rifabutin is active against mycobacterium abscessus in mice

Thomas Dick, Sung Jae Shin, Won Jung Koh, Véronique Dartois, Martin Gengenbacher

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus. Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease.

Original languageEnglish
Article numbere01943
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number2
DOIs
Publication statusPublished - 2020 Jan 27

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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