Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

Dong Hyuk Park, Sul A. Lee, Hyeon Joo Jeong, Tae Hyun Yoo, Shin Wook Kang, Hyung Jung Oh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.

Original languageEnglish
Pages (from-to)582-585
Number of pages4
JournalYonsei medical journal
Volume56
Issue number2
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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