Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

Dong Hyuk Park, Sul A. Lee, Hyeon Joo Jeong, TaeHyun Yoo, Shin-Wook Kang, Hyung Jung Oh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.

Original languageEnglish
Pages (from-to)582-585
Number of pages4
JournalYonsei medical journal
Volume56
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Lipoid Nephrosis
Rifampin
Steroids
Proteinuria
Tuberculosis
Pleural Tuberculosis
Urine
Therapeutics
Serum Albumin
Nausea
Vomiting
Edema
Creatinine
Cholesterol
Kidney
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Park, Dong Hyuk ; Lee, Sul A. ; Jeong, Hyeon Joo ; Yoo, TaeHyun ; Kang, Shin-Wook ; Oh, Hyung Jung. / Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy. In: Yonsei medical journal. 2015 ; Vol. 56, No. 2. pp. 582-585.
@article{44fafec813104e188efb3e3b416bec9d,
title = "Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy",
abstract = "There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.",
author = "Park, {Dong Hyuk} and Lee, {Sul A.} and Jeong, {Hyeon Joo} and TaeHyun Yoo and Shin-Wook Kang and Oh, {Hyung Jung}",
year = "2015",
month = "1",
day = "1",
doi = "10.3349/ymj.2015.56.2.582",
language = "English",
volume = "56",
pages = "582--585",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "2",

}

Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy. / Park, Dong Hyuk; Lee, Sul A.; Jeong, Hyeon Joo; Yoo, TaeHyun; Kang, Shin-Wook; Oh, Hyung Jung.

In: Yonsei medical journal, Vol. 56, No. 2, 01.01.2015, p. 582-585.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

AU - Park, Dong Hyuk

AU - Lee, Sul A.

AU - Jeong, Hyeon Joo

AU - Yoo, TaeHyun

AU - Kang, Shin-Wook

AU - Oh, Hyung Jung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.

AB - There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.

UR - http://www.scopus.com/inward/record.url?scp=84922803888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922803888&partnerID=8YFLogxK

U2 - 10.3349/ymj.2015.56.2.582

DO - 10.3349/ymj.2015.56.2.582

M3 - Article

C2 - 25684013

AN - SCOPUS:84922803888

VL - 56

SP - 582

EP - 585

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 2

ER -