Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)

Kyu Sik Jung, Seung Up Kim, Sang Hoon Ahn, Young Nyun Park, Do Young Kim, Jun Yong Park, Chae Yoon Chon, Eun Hee Choi, Kwang Hyub Han

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB). A total of 1,130 patients with non-biopsy-proven CHB who underwent LSM between May 2005 and December 2007 were enrolled in this prospective study. After LSM was performed, patients attended regular follow-up as part of a surveillance program for the detection of HCC. The mean age of the patients (767 men, 363 women) was 50.2 years, and the median LSM was 7.7 kPa. Six hundred seventy-two (59.5%) patients received antiviral treatment before or after enrollment. During the follow-up period (median, 30.7 months; range, 24.0-50.9 months), HCC developed in 57 patients (2.0% per 1 person-year). The 1-, 2-, and 3-year cumulative incidence rates of HCC were 0.80%, 3.26%, and 5.98%, respectively. On multivariate analysis, together with old age, male sex, heavy alcohol consumption (>80 g/day), serum albumin, and hepatitis B e antigen positivity, patients with a higher LSM (>8 kPa) were at a significantly greater risk of HCC development, with the following hazard ratios: 3.07 (95% confidence interval [CI], 1.01-9.31; P = 0.047) for LSM 8.1-13 kPa; 4.68 (95% CI, 1.40-15.64; P = 0.012) for LSM 13.1-18 kPa; 5.55 (95% CI, 1.53-20.04; P = 0.009) for LSM 18.1-23 kPa; and 6.60 (95% CI, 1.83-23.84; P = 0.004) for LSM >23 kPa. Conclusion: Our data suggest that LSM could be a useful predictor of HCC development in patients with CHB.

Original languageEnglish
Pages (from-to)885-894
Number of pages10
JournalHepatology
Volume53
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Hepatitis B virus
Hepatocellular Carcinoma
Liver
Chronic Hepatitis B
Confidence Intervals
Hepatitis B e Antigens
Chronic Hepatitis C
Serum Albumin
Alcohol Drinking
Liver Cirrhosis
Antiviral Agents
Multivariate Analysis
Prospective Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

@article{763fd92a77344c7faa0a94f75e5a9f7d,
title = "Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)",
abstract = "Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB). A total of 1,130 patients with non-biopsy-proven CHB who underwent LSM between May 2005 and December 2007 were enrolled in this prospective study. After LSM was performed, patients attended regular follow-up as part of a surveillance program for the detection of HCC. The mean age of the patients (767 men, 363 women) was 50.2 years, and the median LSM was 7.7 kPa. Six hundred seventy-two (59.5{\%}) patients received antiviral treatment before or after enrollment. During the follow-up period (median, 30.7 months; range, 24.0-50.9 months), HCC developed in 57 patients (2.0{\%} per 1 person-year). The 1-, 2-, and 3-year cumulative incidence rates of HCC were 0.80{\%}, 3.26{\%}, and 5.98{\%}, respectively. On multivariate analysis, together with old age, male sex, heavy alcohol consumption (>80 g/day), serum albumin, and hepatitis B e antigen positivity, patients with a higher LSM (>8 kPa) were at a significantly greater risk of HCC development, with the following hazard ratios: 3.07 (95{\%} confidence interval [CI], 1.01-9.31; P = 0.047) for LSM 8.1-13 kPa; 4.68 (95{\%} CI, 1.40-15.64; P = 0.012) for LSM 13.1-18 kPa; 5.55 (95{\%} CI, 1.53-20.04; P = 0.009) for LSM 18.1-23 kPa; and 6.60 (95{\%} CI, 1.83-23.84; P = 0.004) for LSM >23 kPa. Conclusion: Our data suggest that LSM could be a useful predictor of HCC development in patients with CHB.",
author = "Jung, {Kyu Sik} and Kim, {Seung Up} and Ahn, {Sang Hoon} and Park, {Young Nyun} and Kim, {Do Young} and Park, {Jun Yong} and Chon, {Chae Yoon} and Choi, {Eun Hee} and Han, {Kwang Hyub}",
year = "2011",
month = "3",
day = "1",
doi = "10.1002/hep.24121",
language = "English",
volume = "53",
pages = "885--894",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan). / Jung, Kyu Sik; Kim, Seung Up; Ahn, Sang Hoon; Park, Young Nyun; Kim, Do Young; Park, Jun Yong; Chon, Chae Yoon; Choi, Eun Hee; Han, Kwang Hyub.

In: Hepatology, Vol. 53, No. 3, 01.03.2011, p. 885-894.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)

AU - Jung, Kyu Sik

AU - Kim, Seung Up

AU - Ahn, Sang Hoon

AU - Park, Young Nyun

AU - Kim, Do Young

AU - Park, Jun Yong

AU - Chon, Chae Yoon

AU - Choi, Eun Hee

AU - Han, Kwang Hyub

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB). A total of 1,130 patients with non-biopsy-proven CHB who underwent LSM between May 2005 and December 2007 were enrolled in this prospective study. After LSM was performed, patients attended regular follow-up as part of a surveillance program for the detection of HCC. The mean age of the patients (767 men, 363 women) was 50.2 years, and the median LSM was 7.7 kPa. Six hundred seventy-two (59.5%) patients received antiviral treatment before or after enrollment. During the follow-up period (median, 30.7 months; range, 24.0-50.9 months), HCC developed in 57 patients (2.0% per 1 person-year). The 1-, 2-, and 3-year cumulative incidence rates of HCC were 0.80%, 3.26%, and 5.98%, respectively. On multivariate analysis, together with old age, male sex, heavy alcohol consumption (>80 g/day), serum albumin, and hepatitis B e antigen positivity, patients with a higher LSM (>8 kPa) were at a significantly greater risk of HCC development, with the following hazard ratios: 3.07 (95% confidence interval [CI], 1.01-9.31; P = 0.047) for LSM 8.1-13 kPa; 4.68 (95% CI, 1.40-15.64; P = 0.012) for LSM 13.1-18 kPa; 5.55 (95% CI, 1.53-20.04; P = 0.009) for LSM 18.1-23 kPa; and 6.60 (95% CI, 1.83-23.84; P = 0.004) for LSM >23 kPa. Conclusion: Our data suggest that LSM could be a useful predictor of HCC development in patients with CHB.

AB - Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB). A total of 1,130 patients with non-biopsy-proven CHB who underwent LSM between May 2005 and December 2007 were enrolled in this prospective study. After LSM was performed, patients attended regular follow-up as part of a surveillance program for the detection of HCC. The mean age of the patients (767 men, 363 women) was 50.2 years, and the median LSM was 7.7 kPa. Six hundred seventy-two (59.5%) patients received antiviral treatment before or after enrollment. During the follow-up period (median, 30.7 months; range, 24.0-50.9 months), HCC developed in 57 patients (2.0% per 1 person-year). The 1-, 2-, and 3-year cumulative incidence rates of HCC were 0.80%, 3.26%, and 5.98%, respectively. On multivariate analysis, together with old age, male sex, heavy alcohol consumption (>80 g/day), serum albumin, and hepatitis B e antigen positivity, patients with a higher LSM (>8 kPa) were at a significantly greater risk of HCC development, with the following hazard ratios: 3.07 (95% confidence interval [CI], 1.01-9.31; P = 0.047) for LSM 8.1-13 kPa; 4.68 (95% CI, 1.40-15.64; P = 0.012) for LSM 13.1-18 kPa; 5.55 (95% CI, 1.53-20.04; P = 0.009) for LSM 18.1-23 kPa; and 6.60 (95% CI, 1.83-23.84; P = 0.004) for LSM >23 kPa. Conclusion: Our data suggest that LSM could be a useful predictor of HCC development in patients with CHB.

UR - http://www.scopus.com/inward/record.url?scp=79952213055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952213055&partnerID=8YFLogxK

U2 - 10.1002/hep.24121

DO - 10.1002/hep.24121

M3 - Article

C2 - 21319193

AN - SCOPUS:79952213055

VL - 53

SP - 885

EP - 894

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 3

ER -