Risk factors affecting seroconversion after influenza A/H1N1 vaccination in hemodialysis patients.

Sung Jin Moon, Sang Hun Lee, Young Ho Byun, Gi Young Yun, Seung Kyu Kim, Baik Lin Seong, Ah Reum Kim, Eun Sun Park, Hyung Jong Kim, Jung Eun Lee, Sung Kyu Ha, Jae Myun Lee, Hyeong Cheon Park

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Hemodialysis (HD) patients have multiple causes of immune dysfunction and poor immune response to influenza vaccination. We investigated the antibody response rate to a pandemic H1N1/2009 influenza vaccination and clinical parameters influencing the induction of antibody responses in HD patients. A total of 114 HD patients were vaccinated with a monovalent adjuvanted H1N1 inactivated influenza vaccine. Titers of neutralizing antibodies were evaluated by hemagglutination inhibition (HI) assay at pre- and 4 weeks after vaccination. Seroconversion was defined as either a pre-vaccination HI titer < 1:10 and a post vaccination HI titer > 1:40 or a pre-vaccination HI titer ≥ 1:10 and a minimum four-fold rise in post-vaccination HI antibody titer. Seventeen out of 114 HD patients (14.9%) tested positive for antibodies against influenza A/H1N1/2009 before vaccination. The remaining 97 baseline sero-negative patients were included in the analysis. Only 30 (30.9%) HD patients had seroconversion 4 weeks after vaccination. The elderly patients, those over 65 years of age, showed significantly lower seroconversion rate compared to younger HD patients (20.5% vs. 39.6%, p = 0.042). Furthermore, patients with hemoglobin values less than 10 g/dL had a significantly lower seroconversion rate compared to those with higher hemoglobin values (20.0 vs. 38.6%, p = 0.049). By multivariate logistic regression analysis, only age ≥65 years (OR = 0.336, 95% confidence interval (CI) 0.116-0.971, p = 0.044) and hemoglobin levels <10 g/dL (OR = 0.315, 95% CI 0.106-0.932, p = 0.037) were independently associated with seroconversion after vaccination. Our data show that HD patients, especially who are elderly with low hemoglobin levels, are at increased risk for lower seroconversion rate after influenza A/H1N1 vaccination. Further studies are needed to improve the efficacy of vaccination in these high risk patients.

Original languageEnglish
Article number165
JournalUnknown Journal
Publication statusPublished - 2012

Bibliographical note

Funding Information:
The authors thank, KJ Kim, WI Park, BS Kang for their help in serum sample collection. This work was supported by research grant from the Yonsei University Industry-Academic Cooperation Foundation (7-2009-0739, HC Park) and the Korea Healthcare Technology R&D project, Ministry of Health and Welfare, Republic of Korea (Grant No. A103001).

All Science Journal Classification (ASJC) codes

  • Nephrology


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