Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis: a Korean multicenter study

Yong Eun Park, Jae Hee Cheon, Jae Jun Park, Yoon Jae Kim, Chang Hwan Choi, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim

Research output: Contribution to journalArticle

Abstract

Background: Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PSC with those of patients with PSC alone are lacking. Methods: We retrospectively reviewed patients with PSC diagnosed between 2005 and 2017 in four tertiary hospitals in Korea. We compared the risk factors and outcomes of concomitant UC and PSC (UC-PSC) and those of PSC alone. Results: PSC was diagnosed in 50 patients in four different tertiary hospitals in Korea. Of them, 18 patients (36.0%) had UC-PSC and 32 patients (64.0%) had PSC alone. The median age at PSC diagnosis was younger in the UC-PSC group than that in the PSC alone group (37 vs. 54 years, P = 0.002). In multivariate analysis, older age at PSC diagnosis (P = 0.007; odds ratio [OR], 0.884; 95% confidence interval [CI], 0.808–0.966) and current smoking habit (P = 0.033; OR, 0.026; 95% CI, 0.001–0.748) were determined to be independent factors for reducing the possibility of developing concomitant UC after PSC. Additionally, UC-PSC was shown to be an independent risk factor for the development of colorectal dysplasia (P = 0.044; OR, 10.829; 95% CI, 1.065–110.127). Conclusions: Our analysis showed that UC-PSC is more likely to be negatively associated with current smoking and older age at the time of PSC diagnosis. Moreover, UC-PSC increased the risk of colorectal dysplasia.

Original languageEnglish
Pages (from-to)1497-1500
Number of pages4
JournalInternational Journal of Colorectal Disease
Volume33
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1

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Sclerosing Cholangitis
Ulcerative Colitis
Multicenter Studies
Odds Ratio
Confidence Intervals
Korea
Tertiary Care Centers
Smoking

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Park, Yong Eun ; Cheon, Jae Hee ; Park, Jae Jun ; Kim, Yoon Jae ; Choi, Chang Hwan ; Park, Yehyun ; Park, Soo Jung ; Kim, Tae Il ; Kim, Won Ho. / Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis : a Korean multicenter study. In: International Journal of Colorectal Disease. 2018 ; Vol. 33, No. 10. pp. 1497-1500.
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title = "Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis: a Korean multicenter study",
abstract = "Background: Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PSC with those of patients with PSC alone are lacking. Methods: We retrospectively reviewed patients with PSC diagnosed between 2005 and 2017 in four tertiary hospitals in Korea. We compared the risk factors and outcomes of concomitant UC and PSC (UC-PSC) and those of PSC alone. Results: PSC was diagnosed in 50 patients in four different tertiary hospitals in Korea. Of them, 18 patients (36.0{\%}) had UC-PSC and 32 patients (64.0{\%}) had PSC alone. The median age at PSC diagnosis was younger in the UC-PSC group than that in the PSC alone group (37 vs. 54 years, P = 0.002). In multivariate analysis, older age at PSC diagnosis (P = 0.007; odds ratio [OR], 0.884; 95{\%} confidence interval [CI], 0.808–0.966) and current smoking habit (P = 0.033; OR, 0.026; 95{\%} CI, 0.001–0.748) were determined to be independent factors for reducing the possibility of developing concomitant UC after PSC. Additionally, UC-PSC was shown to be an independent risk factor for the development of colorectal dysplasia (P = 0.044; OR, 10.829; 95{\%} CI, 1.065–110.127). Conclusions: Our analysis showed that UC-PSC is more likely to be negatively associated with current smoking and older age at the time of PSC diagnosis. Moreover, UC-PSC increased the risk of colorectal dysplasia.",
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Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis : a Korean multicenter study. / Park, Yong Eun; Cheon, Jae Hee; Park, Jae Jun; Kim, Yoon Jae; Choi, Chang Hwan; Park, Yehyun; Park, Soo Jung; Kim, Tae Il; Kim, Won Ho.

In: International Journal of Colorectal Disease, Vol. 33, No. 10, 01.10.2018, p. 1497-1500.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors and clinical courses of concomitant primary sclerosing cholangitis and ulcerative colitis

T2 - a Korean multicenter study

AU - Park, Yong Eun

AU - Cheon, Jae Hee

AU - Park, Jae Jun

AU - Kim, Yoon Jae

AU - Choi, Chang Hwan

AU - Park, Yehyun

AU - Park, Soo Jung

AU - Kim, Tae Il

AU - Kim, Won Ho

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PSC with those of patients with PSC alone are lacking. Methods: We retrospectively reviewed patients with PSC diagnosed between 2005 and 2017 in four tertiary hospitals in Korea. We compared the risk factors and outcomes of concomitant UC and PSC (UC-PSC) and those of PSC alone. Results: PSC was diagnosed in 50 patients in four different tertiary hospitals in Korea. Of them, 18 patients (36.0%) had UC-PSC and 32 patients (64.0%) had PSC alone. The median age at PSC diagnosis was younger in the UC-PSC group than that in the PSC alone group (37 vs. 54 years, P = 0.002). In multivariate analysis, older age at PSC diagnosis (P = 0.007; odds ratio [OR], 0.884; 95% confidence interval [CI], 0.808–0.966) and current smoking habit (P = 0.033; OR, 0.026; 95% CI, 0.001–0.748) were determined to be independent factors for reducing the possibility of developing concomitant UC after PSC. Additionally, UC-PSC was shown to be an independent risk factor for the development of colorectal dysplasia (P = 0.044; OR, 10.829; 95% CI, 1.065–110.127). Conclusions: Our analysis showed that UC-PSC is more likely to be negatively associated with current smoking and older age at the time of PSC diagnosis. Moreover, UC-PSC increased the risk of colorectal dysplasia.

AB - Background: Primary sclerosing cholangitis (PSC) is a rare progressive cholestatic liver disease of unknown causes, but is strongly associated with inflammatory bowel diseases (IBDs), particularly ulcerative colitis (UC). However, studies comparing risk factors and clinical courses of patients with concomitant UC and PSC with those of patients with PSC alone are lacking. Methods: We retrospectively reviewed patients with PSC diagnosed between 2005 and 2017 in four tertiary hospitals in Korea. We compared the risk factors and outcomes of concomitant UC and PSC (UC-PSC) and those of PSC alone. Results: PSC was diagnosed in 50 patients in four different tertiary hospitals in Korea. Of them, 18 patients (36.0%) had UC-PSC and 32 patients (64.0%) had PSC alone. The median age at PSC diagnosis was younger in the UC-PSC group than that in the PSC alone group (37 vs. 54 years, P = 0.002). In multivariate analysis, older age at PSC diagnosis (P = 0.007; odds ratio [OR], 0.884; 95% confidence interval [CI], 0.808–0.966) and current smoking habit (P = 0.033; OR, 0.026; 95% CI, 0.001–0.748) were determined to be independent factors for reducing the possibility of developing concomitant UC after PSC. Additionally, UC-PSC was shown to be an independent risk factor for the development of colorectal dysplasia (P = 0.044; OR, 10.829; 95% CI, 1.065–110.127). Conclusions: Our analysis showed that UC-PSC is more likely to be negatively associated with current smoking and older age at the time of PSC diagnosis. Moreover, UC-PSC increased the risk of colorectal dysplasia.

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