Risk factors and outcomes of bloodstream infections with metallo-β-lactamase-producing Acinetobacter

Yeon A. Kim, Jun Yong Choi, Chang Ki Kim, Chang Oh Kim, Myung Soo Kim, Suk Hoon Choi, Bum Sik Chin, Sang Hoon Han, Han Sung Lee, Hee Kyoung Choi, Su Jin Jeoung, Young Goo Song, Jong Hwa Yum, Dongeun Yong, Kyungwon Lee, June Myung Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The spread of Gram-negative bacilli with acquired metallo-β-lactamase (MBL) threatens the successful treatment of major nosocomial infections. The objective of this study was to evaluate the differences in the clinical characteristics of bacteremia caused by MBL-producing Acinetobacter species and MBL non-producing isolates. Two retrospective case-control studies were conducted using data on patients with Acinetobacter bacteremia, who were admitted between January 2001 and December 2005 at a 1500-bed, tertiary-care teaching hospital. Case group 1 (n=27) included patients from whom imipenem-resistant Acinetobacter was isolated in blood culture, and case group 2 (n=7) consisted of those patients from group 1 who yielded MBL-producing isolates. The control group (n=41) included patients from whom carbapenem-susceptible Acinetobacter isolates were isolated in blood culture. Multivariate analysis revealed that the independent risk factors for imipenem-resistant Acinetobacter bacteremia were neutropenia and prolonged use of carbapenem. The independent risk factors for MBL-producing Acinetobacter bacteremia were neutropenia and prolonged use of cephalosporins. The results of this study suggest that a prolonged use of cephalosporins may be associated with MBL-producing Acinetobacter bacteremia.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalScandinavian Journal of Infectious Diseases
Volume40
Issue number3
DOIs
Publication statusPublished - 2008 Feb 22

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Acinetobacter
Bacteremia
Infection
Carbapenems
Imipenem
Cephalosporins
Neutropenia
Tertiary Healthcare
Cross Infection
Teaching Hospitals
Bacillus
Case-Control Studies
Multivariate Analysis
Control Groups

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kim, Yeon A. ; Choi, Jun Yong ; Kim, Chang Ki ; Kim, Chang Oh ; Kim, Myung Soo ; Choi, Suk Hoon ; Chin, Bum Sik ; Han, Sang Hoon ; Lee, Han Sung ; Choi, Hee Kyoung ; Jeoung, Su Jin ; Song, Young Goo ; Yum, Jong Hwa ; Yong, Dongeun ; Lee, Kyungwon ; Kim, June Myung. / Risk factors and outcomes of bloodstream infections with metallo-β-lactamase-producing Acinetobacter. In: Scandinavian Journal of Infectious Diseases. 2008 ; Vol. 40, No. 3. pp. 234-240.
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abstract = "The spread of Gram-negative bacilli with acquired metallo-β-lactamase (MBL) threatens the successful treatment of major nosocomial infections. The objective of this study was to evaluate the differences in the clinical characteristics of bacteremia caused by MBL-producing Acinetobacter species and MBL non-producing isolates. Two retrospective case-control studies were conducted using data on patients with Acinetobacter bacteremia, who were admitted between January 2001 and December 2005 at a 1500-bed, tertiary-care teaching hospital. Case group 1 (n=27) included patients from whom imipenem-resistant Acinetobacter was isolated in blood culture, and case group 2 (n=7) consisted of those patients from group 1 who yielded MBL-producing isolates. The control group (n=41) included patients from whom carbapenem-susceptible Acinetobacter isolates were isolated in blood culture. Multivariate analysis revealed that the independent risk factors for imipenem-resistant Acinetobacter bacteremia were neutropenia and prolonged use of carbapenem. The independent risk factors for MBL-producing Acinetobacter bacteremia were neutropenia and prolonged use of cephalosporins. The results of this study suggest that a prolonged use of cephalosporins may be associated with MBL-producing Acinetobacter bacteremia.",
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Kim, YA, Choi, JY, Kim, CK, Kim, CO, Kim, MS, Choi, SH, Chin, BS, Han, SH, Lee, HS, Choi, HK, Jeoung, SJ, Song, YG, Yum, JH, Yong, D, Lee, K & Kim, JM 2008, 'Risk factors and outcomes of bloodstream infections with metallo-β-lactamase-producing Acinetobacter', Scandinavian Journal of Infectious Diseases, vol. 40, no. 3, pp. 234-240. https://doi.org/10.1080/00365540701633004

Risk factors and outcomes of bloodstream infections with metallo-β-lactamase-producing Acinetobacter. / Kim, Yeon A.; Choi, Jun Yong; Kim, Chang Ki; Kim, Chang Oh; Kim, Myung Soo; Choi, Suk Hoon; Chin, Bum Sik; Han, Sang Hoon; Lee, Han Sung; Choi, Hee Kyoung; Jeoung, Su Jin; Song, Young Goo; Yum, Jong Hwa; Yong, Dongeun; Lee, Kyungwon; Kim, June Myung.

In: Scandinavian Journal of Infectious Diseases, Vol. 40, No. 3, 22.02.2008, p. 234-240.

Research output: Contribution to journalArticle

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AU - Kim, Yeon A.

AU - Choi, Jun Yong

AU - Kim, Chang Ki

AU - Kim, Chang Oh

AU - Kim, Myung Soo

AU - Choi, Suk Hoon

AU - Chin, Bum Sik

AU - Han, Sang Hoon

AU - Lee, Han Sung

AU - Choi, Hee Kyoung

AU - Jeoung, Su Jin

AU - Song, Young Goo

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AU - Yong, Dongeun

AU - Lee, Kyungwon

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