Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients

Yeon Hur Kyu, Soo Kim Myoung, Seun Kim Yu, Seok Kang Eun, Hyun Nam Jae, Hun Kim So, Mo Nam Chung, Woo Ahn Chul, Soo Cha Bong, Il Kim Soon, Chul Lee Hyun

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS - A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation. RESULTS - The overall incidence of PTDM was 39% at 1 year and 35.1% at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4%; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6%; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7%; and non-PTDM during 7 years (N-PTDM7) (patients who did not develop diabetes mellitus during 7 years), 49.3%. Older age (≥40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (≥25 kg/m2) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of P- and L-PTDM. CONCLUSIONS - Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalDiabetes Care
Volume30
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1

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Allografts
Diabetes Mellitus
Kidney
Transplantation
Glucose
Fasting
Incidence
Insulin
Glucose Tolerance Test
Insulin Resistance
Research Design

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Kyu, Yeon Hur ; Myoung, Soo Kim ; Yu, Seun Kim ; Eun, Seok Kang ; Jae, Hyun Nam ; So, Hun Kim ; Chung, Mo Nam ; Chul, Woo Ahn ; Bong, Soo Cha ; Soon, Il Kim ; Hyun, Chul Lee. / Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients. In: Diabetes Care. 2007 ; Vol. 30, No. 3. pp. 609-615.
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title = "Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients",
abstract = "OBJECTIVE - The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS - A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation. RESULTS - The overall incidence of PTDM was 39{\%} at 1 year and 35.1{\%} at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4{\%}; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6{\%}; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7{\%}; and non-PTDM during 7 years (N-PTDM7) (patients who did not develop diabetes mellitus during 7 years), 49.3{\%}. Older age (≥40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (≥25 kg/m2) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of P- and L-PTDM. CONCLUSIONS - Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM.",
author = "Kyu, {Yeon Hur} and Myoung, {Soo Kim} and Yu, {Seun Kim} and Eun, {Seok Kang} and Jae, {Hyun Nam} and So, {Hun Kim} and Chung, {Mo Nam} and Chul, {Woo Ahn} and Bong, {Soo Cha} and Soon, {Il Kim} and Hyun, {Chul Lee}",
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Kyu, YH, Myoung, SK, Yu, SK, Eun, SK, Jae, HN, So, HK, Chung, MN, Chul, WA, Bong, SC, Soon, IK & Hyun, CL 2007, 'Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients', Diabetes Care, vol. 30, no. 3, pp. 609-615. https://doi.org/10.2337/dc06-1277

Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients. / Kyu, Yeon Hur; Myoung, Soo Kim; Yu, Seun Kim; Eun, Seok Kang; Jae, Hyun Nam; So, Hun Kim; Chung, Mo Nam; Chul, Woo Ahn; Bong, Soo Cha; Soon, Il Kim; Hyun, Chul Lee.

In: Diabetes Care, Vol. 30, No. 3, 01.03.2007, p. 609-615.

Research output: Contribution to journalArticle

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T1 - Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients

AU - Kyu, Yeon Hur

AU - Myoung, Soo Kim

AU - Yu, Seun Kim

AU - Eun, Seok Kang

AU - Jae, Hyun Nam

AU - So, Hun Kim

AU - Chung, Mo Nam

AU - Chul, Woo Ahn

AU - Bong, Soo Cha

AU - Soon, Il Kim

AU - Hyun, Chul Lee

PY - 2007/3/1

Y1 - 2007/3/1

N2 - OBJECTIVE - The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS - A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation. RESULTS - The overall incidence of PTDM was 39% at 1 year and 35.1% at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4%; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6%; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7%; and non-PTDM during 7 years (N-PTDM7) (patients who did not develop diabetes mellitus during 7 years), 49.3%. Older age (≥40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (≥25 kg/m2) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of P- and L-PTDM. CONCLUSIONS - Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM.

AB - OBJECTIVE - The aim of this study was to assess the incidence of posttransplantation diabetes mellitus (PTDM) in renal allograft recipients and to investigate factors contributing to the onset and progression of PTDM and its underlying pathogenic mechanism(s). RESEARCH DESIGN AND METHODS - A total of 77 patients with normal glucose tolerance (NGT) were enrolled in this study. An oral glucose tolerance test was performed 1 week before transplantation and repeated at 1 and 7 years after transplantation. RESULTS - The overall incidence of PTDM was 39% at 1 year and 35.1% at 7 years posttransplantation. The incidence for each category of PTDM was as follows: persistent PTDM (P-PTDM) (patients who developed diabetes mellitus within 1 year of transplantation and remained diabetic during 7 years), 23.4%; transient PTDM (T-PTDM) (patients who developed diabetes mellitus during the 1st year after transplantation but eventually recovered to have NGT), 15.6%; late PTDM (L-PTDM) (patients who developed diabetes mellitus later than 1 year after transplantation), 11.7%; and non-PTDM during 7 years (N-PTDM7) (patients who did not develop diabetes mellitus during 7 years), 49.3%. Older age (≥40 years) at transplantation was a higher risk factor for P-PTDM, whereas a high BMI (≥25 kg/m2) and impaired fasting glucose (IFG) at 1 year posttransplantation were higher risk factors for L-PTDM. Impaired insulin secretion rather than insulin resistance was significantly associated with the development of P- and L-PTDM. CONCLUSIONS - Impaired insulin secretion may be the main mechanism for the development of PTDM. Older age at transplantation seems to be associated with P-PTDM, whereas a high BMI and IFG at 1 year after transplantation were associated with L-PTDM.

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