Abstract
Using the pretransplant bone mineral density (BMD) data records of renal recipients, we retrospectively examined risk factors affecting posttransplant changes in BMD and the effect of antiosteoporosis management. For 294 kidney transplant recipients from January 1996 to September 2003, BMD values were expressed as spine and femur T-scores. Gender, age, pretransplant diabetes, blood type compatibility, mode and duration of dialysis, and previous transplantation were considered to be variables affecting BMD changes. T-test or ANOVA was used to compare risk factors. At the time of transplantation, mean spine T-scores were significantly lower among the retransplant group. Mean femur T-scores were significantly lower among the retransplant group, older patients (older than 45 years), and female recipients. Prolonged hemodialysis (>12 months) and retransplant were risk factors for BMD loss during the first year posttransplant. Early application of antiosteoporosis management was effective to ameliorate posttransplant BMD loss. However, antiosteoporosis management after 1 year posttransplant was relatively ineffective. Pretransplant evaluation of BMD and the possibility of significant BMD loss during the first posttransplant year should not be overlooked. Prophylaxis against bone loss and treatment should be started as soon as possible after transplantation for recipients with either normal or abnormal pretransplant BMD.
| Original language | English |
|---|---|
| Pages (from-to) | 2074-2076 |
| Number of pages | 3 |
| Journal | Transplantation Proceedings |
| Volume | 38 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2006 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Transplantation
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Risk Factors for Changes in Bone Mineral Density and the Effect of Antiosteoporosis Management After Renal Transplantation. / Ahn, H. J.; Kim, H. J.; Kim, YuSeun; Kim, M. S.; Huh, K. H.; Kim, J. H.; Lee, J. H.; Jeon, K. O.; Kim, S. I.
In: Transplantation Proceedings, Vol. 38, No. 7, 01.09.2006, p. 2074-2076.Research output: Contribution to journal › Article
TY - JOUR
T1 - Risk Factors for Changes in Bone Mineral Density and the Effect of Antiosteoporosis Management After Renal Transplantation
AU - Ahn, H. J.
AU - Kim, H. J.
AU - Kim, YuSeun
AU - Kim, M. S.
AU - Huh, K. H.
AU - Kim, J. H.
AU - Lee, J. H.
AU - Jeon, K. O.
AU - Kim, S. I.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Using the pretransplant bone mineral density (BMD) data records of renal recipients, we retrospectively examined risk factors affecting posttransplant changes in BMD and the effect of antiosteoporosis management. For 294 kidney transplant recipients from January 1996 to September 2003, BMD values were expressed as spine and femur T-scores. Gender, age, pretransplant diabetes, blood type compatibility, mode and duration of dialysis, and previous transplantation were considered to be variables affecting BMD changes. T-test or ANOVA was used to compare risk factors. At the time of transplantation, mean spine T-scores were significantly lower among the retransplant group. Mean femur T-scores were significantly lower among the retransplant group, older patients (older than 45 years), and female recipients. Prolonged hemodialysis (>12 months) and retransplant were risk factors for BMD loss during the first year posttransplant. Early application of antiosteoporosis management was effective to ameliorate posttransplant BMD loss. However, antiosteoporosis management after 1 year posttransplant was relatively ineffective. Pretransplant evaluation of BMD and the possibility of significant BMD loss during the first posttransplant year should not be overlooked. Prophylaxis against bone loss and treatment should be started as soon as possible after transplantation for recipients with either normal or abnormal pretransplant BMD.
AB - Using the pretransplant bone mineral density (BMD) data records of renal recipients, we retrospectively examined risk factors affecting posttransplant changes in BMD and the effect of antiosteoporosis management. For 294 kidney transplant recipients from January 1996 to September 2003, BMD values were expressed as spine and femur T-scores. Gender, age, pretransplant diabetes, blood type compatibility, mode and duration of dialysis, and previous transplantation were considered to be variables affecting BMD changes. T-test or ANOVA was used to compare risk factors. At the time of transplantation, mean spine T-scores were significantly lower among the retransplant group. Mean femur T-scores were significantly lower among the retransplant group, older patients (older than 45 years), and female recipients. Prolonged hemodialysis (>12 months) and retransplant were risk factors for BMD loss during the first year posttransplant. Early application of antiosteoporosis management was effective to ameliorate posttransplant BMD loss. However, antiosteoporosis management after 1 year posttransplant was relatively ineffective. Pretransplant evaluation of BMD and the possibility of significant BMD loss during the first posttransplant year should not be overlooked. Prophylaxis against bone loss and treatment should be started as soon as possible after transplantation for recipients with either normal or abnormal pretransplant BMD.
UR - http://www.scopus.com/inward/record.url?scp=33846034850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846034850&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2006.06.106
DO - 10.1016/j.transproceed.2006.06.106
M3 - Article
C2 - 16980003
AN - SCOPUS:33846034850
VL - 38
SP - 2074
EP - 2076
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 7
ER -