Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer

I. Cho, J. Y. An, I. G. Kwon, Y. Y. Choi, J. H. Cheong, WooJin Hyung, S. H. Noh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims We carried out a large scale study to identify the risk factors for double primary malignancy (DPM) development in gastric cancer patients and to evaluate the clinical implications for these patients. Methods A total of 2593 patients who underwent gastrectomy for primary gastric cancer from January 2005 to November 2010 were reviewed with regard to DPM. We compared the clinicopathological characteristics, risk factors for developing DPM, and prognosis between the DPM(+) group and the DPM(-) group. Results Of the 2593 patients, 152 (5.9%) were diagnosed with DPM. The most common accompanying malignancies were colorectal, lung and thyroid. Multivariate analysis indicated that age (p = 0.016) and MSI status (p = 0.002) were associated with a higher frequency of DPM. 30.3% of patients were diagnosed with DPM within 1 year around perioperative period and 53.3% of patients had DPM detected during 5 years of post-operative follow up periods. Although there was no significant difference in overall survival between the DPM(+) and DPM(-) group, DPM(+) patients had a worse prognosis than DPM(-) patients in stage I gastric cancer. Conclusions Gastric cancer patients over the age of 60 or with a MSI-high status had an increased risk for developing DPM. Further, in stage I gastric cancer, the presence of DPM was associated with a worse prognosis. Therefore, careful pre- and postoperative surveillance is especially important in these patients.

Original languageEnglish
Pages (from-to)338-344
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume40
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

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Stomach Neoplasms
Neoplasms
Perioperative Period
Gastrectomy
Thyroid Gland
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Cho, I. ; An, J. Y. ; Kwon, I. G. ; Choi, Y. Y. ; Cheong, J. H. ; Hyung, WooJin ; Noh, S. H. / Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer. In: European Journal of Surgical Oncology. 2014 ; Vol. 40, No. 3. pp. 338-344.
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abstract = "Aims We carried out a large scale study to identify the risk factors for double primary malignancy (DPM) development in gastric cancer patients and to evaluate the clinical implications for these patients. Methods A total of 2593 patients who underwent gastrectomy for primary gastric cancer from January 2005 to November 2010 were reviewed with regard to DPM. We compared the clinicopathological characteristics, risk factors for developing DPM, and prognosis between the DPM(+) group and the DPM(-) group. Results Of the 2593 patients, 152 (5.9{\%}) were diagnosed with DPM. The most common accompanying malignancies were colorectal, lung and thyroid. Multivariate analysis indicated that age (p = 0.016) and MSI status (p = 0.002) were associated with a higher frequency of DPM. 30.3{\%} of patients were diagnosed with DPM within 1 year around perioperative period and 53.3{\%} of patients had DPM detected during 5 years of post-operative follow up periods. Although there was no significant difference in overall survival between the DPM(+) and DPM(-) group, DPM(+) patients had a worse prognosis than DPM(-) patients in stage I gastric cancer. Conclusions Gastric cancer patients over the age of 60 or with a MSI-high status had an increased risk for developing DPM. Further, in stage I gastric cancer, the presence of DPM was associated with a worse prognosis. Therefore, careful pre- and postoperative surveillance is especially important in these patients.",
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Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer. / Cho, I.; An, J. Y.; Kwon, I. G.; Choi, Y. Y.; Cheong, J. H.; Hyung, WooJin; Noh, S. H.

In: European Journal of Surgical Oncology, Vol. 40, No. 3, 01.03.2014, p. 338-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer

AU - Cho, I.

AU - An, J. Y.

AU - Kwon, I. G.

AU - Choi, Y. Y.

AU - Cheong, J. H.

AU - Hyung, WooJin

AU - Noh, S. H.

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N2 - Aims We carried out a large scale study to identify the risk factors for double primary malignancy (DPM) development in gastric cancer patients and to evaluate the clinical implications for these patients. Methods A total of 2593 patients who underwent gastrectomy for primary gastric cancer from January 2005 to November 2010 were reviewed with regard to DPM. We compared the clinicopathological characteristics, risk factors for developing DPM, and prognosis between the DPM(+) group and the DPM(-) group. Results Of the 2593 patients, 152 (5.9%) were diagnosed with DPM. The most common accompanying malignancies were colorectal, lung and thyroid. Multivariate analysis indicated that age (p = 0.016) and MSI status (p = 0.002) were associated with a higher frequency of DPM. 30.3% of patients were diagnosed with DPM within 1 year around perioperative period and 53.3% of patients had DPM detected during 5 years of post-operative follow up periods. Although there was no significant difference in overall survival between the DPM(+) and DPM(-) group, DPM(+) patients had a worse prognosis than DPM(-) patients in stage I gastric cancer. Conclusions Gastric cancer patients over the age of 60 or with a MSI-high status had an increased risk for developing DPM. Further, in stage I gastric cancer, the presence of DPM was associated with a worse prognosis. Therefore, careful pre- and postoperative surveillance is especially important in these patients.

AB - Aims We carried out a large scale study to identify the risk factors for double primary malignancy (DPM) development in gastric cancer patients and to evaluate the clinical implications for these patients. Methods A total of 2593 patients who underwent gastrectomy for primary gastric cancer from January 2005 to November 2010 were reviewed with regard to DPM. We compared the clinicopathological characteristics, risk factors for developing DPM, and prognosis between the DPM(+) group and the DPM(-) group. Results Of the 2593 patients, 152 (5.9%) were diagnosed with DPM. The most common accompanying malignancies were colorectal, lung and thyroid. Multivariate analysis indicated that age (p = 0.016) and MSI status (p = 0.002) were associated with a higher frequency of DPM. 30.3% of patients were diagnosed with DPM within 1 year around perioperative period and 53.3% of patients had DPM detected during 5 years of post-operative follow up periods. Although there was no significant difference in overall survival between the DPM(+) and DPM(-) group, DPM(+) patients had a worse prognosis than DPM(-) patients in stage I gastric cancer. Conclusions Gastric cancer patients over the age of 60 or with a MSI-high status had an increased risk for developing DPM. Further, in stage I gastric cancer, the presence of DPM was associated with a worse prognosis. Therefore, careful pre- and postoperative surveillance is especially important in these patients.

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