Risk factors for extended-spectrum-β-lactamaseproducing Escherichia coli in community-onset bloodstream infection: Impact on long-term care hospitals in Korea

Yae Jee Baek, Young Ah Kim, Dokyun Kim, Jong Hee Shin, Young Uh, Kyeong Seob Shin, Jeong Hwan Shin, Seok Hoon Jeong, Geun Woo Lee, Eun Ji Lee, Dong Sook Kim, Yoon Soo Park

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The prevalence of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) in the community has increased worldwide due to multifactorial reasons. ESBL-EC bloodstream infection (BSI) complicates the decision for proper antimicrobial administration. In this multicenter study, we investigated the prevalence, risk factors, and molecular background of community-onset (CO) ESBL-EC BSI. Methods: We included data for all episodes of ESBL-EC BSI of community origin from May 2016 to April 2017 obtained from the Korean national antimicrobial resistance surveillance system, which comprises six sentinel hospitals. Data, including previous history of admission and use of antimicrobials and medical devices before BSI, were collected, along with microbiological analysis results. Results: Among 1,189 patients with CO BSI caused by E. coli, 316 (27%) were identified as ESBL producers. History of admission, especially to a long-term care hospital (LTCH), and previous use of β-lactams/β-lactamase inhibitors, carbapenem, lincosamide, aminoglycoside, and extended-spectrum cephalosporin were independent risk factors for CO ESBL-EC BSI; admission to an LTCH showed the highest odds ratio (3.8, 95% confidence interval 2.3-6.1). The most common genotype was CTX-M-15 (N=131, 41%), followed by CTX-M-14 (N=86, 27%). ST131 was the most common sequence type among ESBL-EC groups (57%). Conclusions: In Korea, 27% of CO E. coli BSI were caused by ESBL producers. From perspectives of empirical treatment and infection control, history of admission to an LTCH and antimicrobial use should be noted.

Original languageEnglish
Pages (from-to)455-462
Number of pages8
JournalAnnals of laboratory medicine
Volume41
Issue number5
DOIs
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
The study was supported by the research programs funded by the Korea Centers for Disease Control & Prevention (2017E280-401#, PI: YSP; 2017E4400100#, PI: SHJ).

Publisher Copyright:
© Korean Society for Laboratory Medicine

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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