Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus

C. H. Suh, Y. S. Jeong, H. C. Park, C. H. Lee, J. Lee, C. H. Song, W. K. Lee, Y. B. Park, J. Song, S. K. Lee

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Abstract

To evaluate risk factors for infection and the role of C-reactive protein (CRP) in the diagnosis of infection, a retrospective case control study was performed among Korean systemic lupus erythematosus patients. Of 120 proven infections, 31 episodes (25.8%) occurred in patients taking no corticosteroids (CS). The risk of infection was lower in patients taking low-dose CS (< 300 mg prednisolone/month) than no CS (odds ratio (OR) 0.36). In patients receiving high-dose CS (> 1000 mg prednisolone/month), however, the risk increased (OR 2.9). In patients taking no CS, disease activity manifested as increased SLEDAI, anemia and active urinary sediment, was associated with infection. The CRP was higher in the patients with infection than controls and the CRP levels over 50 mg/l were observed only in infection. These results suggest that CS have a bimodal influence on infection depending on dose. Disease activity is an important risk factor for infection in patients taking no CS. Finally, CRP levels greater than 50 mg/l suggest the presence of infection.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalClinical and experimental rheumatology
Volume19
Issue number2
Publication statusPublished - 2001 May 7

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Systemic Lupus Erythematosus
C-Reactive Protein
Infection
Adrenal Cortex Hormones
Infection Control
Prednisolone
Case-Control Studies
Anemia

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Suh, C. H., Jeong, Y. S., Park, H. C., Lee, C. H., Lee, J., Song, C. H., ... Lee, S. K. (2001). Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus. Clinical and experimental rheumatology, 19(2), 191-194.
Suh, C. H. ; Jeong, Y. S. ; Park, H. C. ; Lee, C. H. ; Lee, J. ; Song, C. H. ; Lee, W. K. ; Park, Y. B. ; Song, J. ; Lee, S. K. / Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus. In: Clinical and experimental rheumatology. 2001 ; Vol. 19, No. 2. pp. 191-194.
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Suh, CH, Jeong, YS, Park, HC, Lee, CH, Lee, J, Song, CH, Lee, WK, Park, YB, Song, J & Lee, SK 2001, 'Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus', Clinical and experimental rheumatology, vol. 19, no. 2, pp. 191-194.

Risk factors for infection and role of C-reactive protein in Korean patients with systemic lupus erythematosus. / Suh, C. H.; Jeong, Y. S.; Park, H. C.; Lee, C. H.; Lee, J.; Song, C. H.; Lee, W. K.; Park, Y. B.; Song, J.; Lee, S. K.

In: Clinical and experimental rheumatology, Vol. 19, No. 2, 07.05.2001, p. 191-194.

Research output: Contribution to journalArticle

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AU - Suh, C. H.

AU - Jeong, Y. S.

AU - Park, H. C.

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AU - Lee, J.

AU - Song, C. H.

AU - Lee, W. K.

AU - Park, Y. B.

AU - Song, J.

AU - Lee, S. K.

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N2 - To evaluate risk factors for infection and the role of C-reactive protein (CRP) in the diagnosis of infection, a retrospective case control study was performed among Korean systemic lupus erythematosus patients. Of 120 proven infections, 31 episodes (25.8%) occurred in patients taking no corticosteroids (CS). The risk of infection was lower in patients taking low-dose CS (< 300 mg prednisolone/month) than no CS (odds ratio (OR) 0.36). In patients receiving high-dose CS (> 1000 mg prednisolone/month), however, the risk increased (OR 2.9). In patients taking no CS, disease activity manifested as increased SLEDAI, anemia and active urinary sediment, was associated with infection. The CRP was higher in the patients with infection than controls and the CRP levels over 50 mg/l were observed only in infection. These results suggest that CS have a bimodal influence on infection depending on dose. Disease activity is an important risk factor for infection in patients taking no CS. Finally, CRP levels greater than 50 mg/l suggest the presence of infection.

AB - To evaluate risk factors for infection and the role of C-reactive protein (CRP) in the diagnosis of infection, a retrospective case control study was performed among Korean systemic lupus erythematosus patients. Of 120 proven infections, 31 episodes (25.8%) occurred in patients taking no corticosteroids (CS). The risk of infection was lower in patients taking low-dose CS (< 300 mg prednisolone/month) than no CS (odds ratio (OR) 0.36). In patients receiving high-dose CS (> 1000 mg prednisolone/month), however, the risk increased (OR 2.9). In patients taking no CS, disease activity manifested as increased SLEDAI, anemia and active urinary sediment, was associated with infection. The CRP was higher in the patients with infection than controls and the CRP levels over 50 mg/l were observed only in infection. These results suggest that CS have a bimodal influence on infection depending on dose. Disease activity is an important risk factor for infection in patients taking no CS. Finally, CRP levels greater than 50 mg/l suggest the presence of infection.

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