Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: Clinical impact of bacterial virulence and strains on outcome

Su Jin Jeong, Sang Sun Yoon, Il Kwon Bae, Seokhoon Jeong, June Myung Kim, Kyungwon Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteremia. Data on 63 episodes of CRPA bacteremia that have occurred between January 1, 2007, and December 31, 2009, in a teaching hospital (2000 beds) in Seoul, Korea, were analyzed. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score at the time of CRPA bacteremia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteremia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume80
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Carbapenems
Pseudomonas aeruginosa
Virulence
Bacteremia
Mortality
Infection
APACHE
Biofilms
Pancreatic Elastase
Virulence Factors
Korea
Teaching Hospitals
Incidence

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{624d09ca357840a4972fa634c719df3c,
title = "Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: Clinical impact of bacterial virulence and strains on outcome",
abstract = "The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteremia. Data on 63 episodes of CRPA bacteremia that have occurred between January 1, 2007, and December 31, 2009, in a teaching hospital (2000 beds) in Seoul, Korea, were analyzed. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score at the time of CRPA bacteremia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteremia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.",
author = "Jeong, {Su Jin} and Yoon, {Sang Sun} and Bae, {Il Kwon} and Seokhoon Jeong and Kim, {June Myung} and Kyungwon Lee",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.diagmicrobio.2014.07.003",
language = "English",
volume = "80",
pages = "130--135",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa

T2 - Clinical impact of bacterial virulence and strains on outcome

AU - Jeong, Su Jin

AU - Yoon, Sang Sun

AU - Bae, Il Kwon

AU - Jeong, Seokhoon

AU - Kim, June Myung

AU - Lee, Kyungwon

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteremia. Data on 63 episodes of CRPA bacteremia that have occurred between January 1, 2007, and December 31, 2009, in a teaching hospital (2000 beds) in Seoul, Korea, were analyzed. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score at the time of CRPA bacteremia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteremia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.

AB - The incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) bacteremia has increased in recent years, and infections caused by CRPA result in higher mortality than those caused by susceptible strains. This study was performed to evaluate the risk factors for mortality and to study the impact of virulence factors and bacterial strains on clinical outcomes in patients with CRPA bacteremia. Data on 63 episodes of CRPA bacteremia that have occurred between January 1, 2007, and December 31, 2009, in a teaching hospital (2000 beds) in Seoul, Korea, were analyzed. The Acute Physiology and Chronic Health Evaluation II (APACHE II) score at the time of CRPA bacteremia and the capacity of CRPA to form biofilm were independent predictive factors for mortality in patients with CRPA bacteremia. In addition, the biofilm-forming ability and elastase activity of strains were correlated with APACHE II scores to measure the severity of disease and estimate predicted mortality in the patients.

UR - http://www.scopus.com/inward/record.url?scp=84928522861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928522861&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2014.07.003

DO - 10.1016/j.diagmicrobio.2014.07.003

M3 - Article

C2 - 25112900

AN - SCOPUS:84928522861

VL - 80

SP - 130

EP - 135

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

IS - 2

ER -