Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia

Nam Su Ku, Sang Hoon Han, Chang Oh Kim, Ji Hyeon Baek, Su Jin Jeong, Sung Joon Jin, JunYong Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia. Methods: Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture. Results: The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively). Conclusions: An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Volume43
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

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Burkholderia cepacia complex
Bacteremia
Organ Dysfunction Scores
Mortality
Korea
Critical Illness
Intensive Care Units
Diabetes Mellitus
Therapeutics
Multivariate Analysis
Medicine
Outcome Assessment (Health Care)
Morbidity

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Ku, N. S., Han, S. H., Kim, C. O., Baek, J. H., Jeong, S. J., Jin, S. J., ... Kim, J. M. (2011). Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. Scandinavian Journal of Infectious Diseases, 43(10), 792-797. https://doi.org/10.3109/00365548.2011.589076
Ku, Nam Su ; Han, Sang Hoon ; Kim, Chang Oh ; Baek, Ji Hyeon ; Jeong, Su Jin ; Jin, Sung Joon ; Choi, JunYong ; Song, Young Goo ; Kim, June Myung. / Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. In: Scandinavian Journal of Infectious Diseases. 2011 ; Vol. 43, No. 10. pp. 792-797.
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Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia. / Ku, Nam Su; Han, Sang Hoon; Kim, Chang Oh; Baek, Ji Hyeon; Jeong, Su Jin; Jin, Sung Joon; Choi, JunYong; Song, Young Goo; Kim, June Myung.

In: Scandinavian Journal of Infectious Diseases, Vol. 43, No. 10, 01.10.2011, p. 792-797.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia

AU - Ku, Nam Su

AU - Han, Sang Hoon

AU - Kim, Chang Oh

AU - Baek, Ji Hyeon

AU - Jeong, Su Jin

AU - Jin, Sung Joon

AU - Choi, JunYong

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Background: Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia. Methods: Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture. Results: The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively). Conclusions: An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.

AB - Background: Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia. Methods: Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture. Results: The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively). Conclusions: An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.

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U2 - 10.3109/00365548.2011.589076

DO - 10.3109/00365548.2011.589076

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