Risk factors for mortality in patients with serratia marcescens bacteremia

Sun Bean Kim, Yong Duk Jeon, Jung Ho Kim, Jae Kyoung Kim, Hea Won Ann, Heun Choi, Min Hyung Kim, Je Eun Song, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. Materials and Methods: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. Results: The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044‒0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200‒1.810, p<0.001, respectively]. Conclusion: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalYonsei medical journal
Volume56
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

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Serratia marcescens
Bacteremia
Serum Albumin
Mortality
Odds Ratio
Urinary Catheters
Republic of Korea
Indwelling Catheters
Tertiary Healthcare
Cross Infection
Tertiary Care Centers
C-Reactive Protein
Intensive Care Units
Blood Proteins
Cohort Studies
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Kim, S. B., Jeon, Y. D., Kim, J. H., Kim, J. K., Ann, H. W., Choi, H., ... Kim, J. M. (2015). Risk factors for mortality in patients with serratia marcescens bacteremia. Yonsei medical journal, 56(2), 348-354. https://doi.org/10.3349/ymj.2015.56.2.348
Kim, Sun Bean ; Jeon, Yong Duk ; Kim, Jung Ho ; Kim, Jae Kyoung ; Ann, Hea Won ; Choi, Heun ; Kim, Min Hyung ; Song, Je Eun ; Ahn, Jin Young ; Jeong, Su Jin ; Ku, Nam Su ; Han, Sang Hoon ; Choi, Jun Yong ; Song, Young Goo ; Kim, June Myung. / Risk factors for mortality in patients with serratia marcescens bacteremia. In: Yonsei medical journal. 2015 ; Vol. 56, No. 2. pp. 348-354.
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abstract = "Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. Materials and Methods: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. Results: The 28-day mortality was 22.4{\%} (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95{\%} confidential interval (CI) 0.044‒0.960, p=0.040, and adjusted OR 1.474, 95{\%} CI 1.200‒1.810, p<0.001, respectively]. Conclusion: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.",
author = "Kim, {Sun Bean} and Jeon, {Yong Duk} and Kim, {Jung Ho} and Kim, {Jae Kyoung} and Ann, {Hea Won} and Heun Choi and Kim, {Min Hyung} and Song, {Je Eun} and Ahn, {Jin Young} and Jeong, {Su Jin} and Ku, {Nam Su} and Han, {Sang Hoon} and Choi, {Jun Yong} and Song, {Young Goo} and Kim, {June Myung}",
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Kim, SB, Jeon, YD, Kim, JH, Kim, JK, Ann, HW, Choi, H, Kim, MH, Song, JE, Ahn, JY, Jeong, SJ, Ku, NS, Han, SH, Choi, JY, Song, YG & Kim, JM 2015, 'Risk factors for mortality in patients with serratia marcescens bacteremia', Yonsei medical journal, vol. 56, no. 2, pp. 348-354. https://doi.org/10.3349/ymj.2015.56.2.348

Risk factors for mortality in patients with serratia marcescens bacteremia. / Kim, Sun Bean; Jeon, Yong Duk; Kim, Jung Ho; Kim, Jae Kyoung; Ann, Hea Won; Choi, Heun; Kim, Min Hyung; Song, Je Eun; Ahn, Jin Young; Jeong, Su Jin; Ku, Nam Su; Han, Sang Hoon; Choi, Jun Yong; Song, Young Goo; Kim, June Myung.

In: Yonsei medical journal, Vol. 56, No. 2, 01.01.2015, p. 348-354.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for mortality in patients with serratia marcescens bacteremia

AU - Kim, Sun Bean

AU - Jeon, Yong Duk

AU - Kim, Jung Ho

AU - Kim, Jae Kyoung

AU - Ann, Hea Won

AU - Choi, Heun

AU - Kim, Min Hyung

AU - Song, Je Eun

AU - Ahn, Jin Young

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Han, Sang Hoon

AU - Choi, Jun Yong

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. Materials and Methods: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. Results: The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044‒0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200‒1.810, p<0.001, respectively]. Conclusion: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.

AB - Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. Materials and Methods: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. Results: The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044‒0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200‒1.810, p<0.001, respectively]. Conclusion: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.

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