Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia

Yong Duk Jeon, Woo Yong Jeong, Moo Hyun Kim, In Young Jung, Mi Young Ahn, Hea Won Ann, Jin Young Ahn, Sang Hoon Han, JunYong Choi, Young Goo Song, June Myung Kim, Nam Su Ku

Research output: Contribution to journalArticle

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Abstract

Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia. Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality. In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality. Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.

Original languageEnglish
Article numbere4375
JournalMedicine (United States)
Volume95
Issue number31
DOIs
Publication statusPublished - 2016 Aug 1

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Mortality
Central Venous Catheters
Organ Dysfunction Scores
Sepsis
Odds Ratio
Confidence Intervals
Stenotrophomonas maltophilia
APACHE
Hematologic Neoplasms
Tertiary Healthcare
Korea
Bacteremia
Stenotrophomonas maltophilia bacteremia
Tertiary Care Centers
Critical Illness
Medical Records
Intensive Care Units
Multivariate Analysis
Morbidity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jung, I. Y., Ahn, M. Y., Ann, H. W., ... Ku, N. S. (2016). Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia. Medicine (United States), 95(31), [e4375]. https://doi.org/10.1097/MD.0000000000004375
Jeon, Yong Duk ; Jeong, Woo Yong ; Kim, Moo Hyun ; Jung, In Young ; Ahn, Mi Young ; Ann, Hea Won ; Ahn, Jin Young ; Han, Sang Hoon ; Choi, JunYong ; Song, Young Goo ; Kim, June Myung ; Ku, Nam Su. / Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia. In: Medicine (United States). 2016 ; Vol. 95, No. 31.
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abstract = "Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia. Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality. In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6{\%}. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95{\%} confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95{\%} CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality. Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.",
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Jeon, YD, Jeong, WY, Kim, MH, Jung, IY, Ahn, MY, Ann, HW, Ahn, JY, Han, SH, Choi, J, Song, YG, Kim, JM & Ku, NS 2016, 'Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia', Medicine (United States), vol. 95, no. 31, e4375. https://doi.org/10.1097/MD.0000000000004375

Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia. / Jeon, Yong Duk; Jeong, Woo Yong; Kim, Moo Hyun; Jung, In Young; Ahn, Mi Young; Ann, Hea Won; Ahn, Jin Young; Han, Sang Hoon; Choi, JunYong; Song, Young Goo; Kim, June Myung; Ku, Nam Su.

In: Medicine (United States), Vol. 95, No. 31, e4375, 01.08.2016.

Research output: Contribution to journalArticle

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T1 - Risk factors for mortality in patients with Stenotrophomonas maltophilia bacteremia

AU - Jeon, Yong Duk

AU - Jeong, Woo Yong

AU - Kim, Moo Hyun

AU - Jung, In Young

AU - Ahn, Mi Young

AU - Ann, Hea Won

AU - Ahn, Jin Young

AU - Han, Sang Hoon

AU - Choi, JunYong

AU - Song, Young Goo

AU - Kim, June Myung

AU - Ku, Nam Su

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia. Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality. In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality. Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.

AB - Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality in patients with S. maltophilia bacteremia. Retrospectively, medical records from all patients with S. maltophilia bacteremia between December 2005 and 2014 at Severance Hospital, a 2000-bed tertiary care hospital in Seoul, Korea, were reviewed. Analysis was performed to identify factors associated with 28-day mortality. In total, 142 bacteremia patients were enrolled in this study. The overall 28-day mortality rate was 36.6%. Based on the univariate analysis, hematologic malignancy (P = 0.015), Sepsis-related Organ Failure Assessment (SOFA) score (P < 0.001) and the removal of a central venous catheter (CVC) (P = 0.040) were significantly related to mortality. In the intensive care unit patients, the Acute Physiology and Chronic Health Evaluation II score (P = 0.001) also had significance. Based on the multivariate analysis, the SOFA score (odds ratio [OR] = 1.323; 95% confidence interval [CI]: 1.159, 1.509; P < 0.001) and removal of the CVC (OR = 0.330; 95% CI: 0.109, 0.996; P = 0.049) were independent factors associated with mortality. Our results suggest that removing a CVC may considerably reduce mortality in patients with S. maltophilia bacteremia.

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