Risk factors for occurrence and 30-day mortality for carbapenem-resistant Acinetobacter baumannii bacteremia in an intensive care unit

Song Yee Kim, Ji Ye Jung, Young Ae Kang, Joo Eun Lim, Eun Young Kim, Sang Kook Lee, Seon Cheol Park, Kyung Soo Chung, Byung Hoon Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park

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Abstract

To assess the risk factors for carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia and for 30-day mortality in patients with CRAB bacteremia in the intensive care unit (ICU), we conducted a retrospective study in the ICU at Severance Hospital in Korea from January 2008 to December 2009. Patients who acquired CRAB bacteremia in the ICU were enrolled as the case group and patients whose specimens of blood culture, sputum/endotracheal aspirate and urine revealed no AB were enrolled as controls. The case group comprised 106 patients and 205 patients were included as controls. Risk factors independently associated with CRAB bacteremia included prior chemotherapy or radiotherapy treatment (Odds ratio [OR], 3.6; P = 0.003), recent central venous catheter insertion (OR, 5.7; P < 0.001) or abdominal drainage insertion (OR, 21.9; P = 0.004), the number of antibiotics treated with (OR, 1.3; P = 0.016), and respiratory failure in the ICU (OR, 2.5; P = 0.035). The 30-day mortality was 79.8%. Renal failure during ICU stay was independently associated with 30-day mortality (OR, 3.7; P = 0.047). It is important to minimize invasive procedures, and to restrict excessive use of antibiotics, especially in immunocompromised patients, in order to prevent the development of CRAB bacteremia. Greater concern for CRAB bacteremia patients is needed when renal failure develops during ICU stay.

Original languageEnglish
Pages (from-to)939-947
Number of pages9
JournalJournal of Korean medical science
Volume27
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, S. Y., Jung, J. Y., Kang, Y. A., Lim, J. E., Kim, E. Y., Lee, S. K., Park, S. C., Chung, K. S., Park, B. H., Kim, Y. S., Kim, S. K., Chang, J., & Park, M. S. (2012). Risk factors for occurrence and 30-day mortality for carbapenem-resistant Acinetobacter baumannii bacteremia in an intensive care unit. Journal of Korean medical science, 27(8), 939-947. https://doi.org/10.3346/jkms.2012.27.8.939