Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients possess multiple risk factors for osteoporosis, but few studies have evaluated bone mineral density (BMD) in CIDP patients. Methods: We retrospectively compared the BMD of CIDP patients with that of normal controls, and evaluated the clinical factors associated with osteoporosis. Results: Total BMD was lower in CIDP patients than in normal controls (P = 0.017). In a comparison of 16 osteoporotic CIDP patients with 25 non-osteoporotic patients, the cumulative prednisolone dose was lower (P = 0.022) and the duration from disease onset to BMD measurement was shorter (P = 0.014) in osteoporotic patients than in non-osteoporotic patients. Function, as measured by modified Rankin scale score within 3 years of the BMD measurement, was worse in osteoporotic than in non-osteoporotic patients (P = 0.008). Discussion: BMD in CIDP patients was significantly lower than in normal controls. Functional status rather than cumulative steroid dose was associated with osteoporosis. Muscle Nerve 58: 407–412, 2018.
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Abbreviations: BMD, bone mineral density; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; DXA, dual-energy X-ray absorpti-ometry; MRC, Medical Research Council; mRS, modified Rankin scale Key words: bone mineral density; chronic inflammatory demyelinating polyradiculoneuropathy; corticosteroid; inflammatory neuropathy; osteoporosis Funding: National Research Foundation of Korea, grant NRF-2016R1C1B1010120.
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)