Risk factors for the acquisition of carbapenem-resistant Escherichia coli at a tertiary care center in South Korea: A matched case-control study

Jin Young Ahn, Je Eun Song, Min Hyung Kim, Heun Choi, Jae Kyung Kim, Hea Won Ann, Jung Ho Kim, Yongduk Jeon, Su Jin Jeong, Sun Bean Kim, Nam Su Ku, Sang Hoon Han, Young Goo Song, Dongeun Yong, Kyungwon Lee, June Myung Kim, Jun Yong Choi

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Abstract

Background Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE). Methods We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea. Results On univariate analysis, previous use of carbapenem (P <.01), fluoroquinolone (P <.01), and glycopeptide (P <.01), as well as length of hospital stay (P <.05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P =.01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P =.03) were independent risk factors. Conclusions At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalAmerican Journal of Infection Control
Volume42
Issue number6
DOIs
Publication statusPublished - 2014 Jun

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Ahn, J. Y., Song, J. E., Kim, M. H., Choi, H., Kim, J. K., Ann, H. W., Kim, J. H., Jeon, Y., Jeong, S. J., Kim, S. B., Ku, N. S., Han, S. H., Song, Y. G., Yong, D., Lee, K., Kim, J. M., & Choi, J. Y. (2014). Risk factors for the acquisition of carbapenem-resistant Escherichia coli at a tertiary care center in South Korea: A matched case-control study. American Journal of Infection Control, 42(6), 621-625. https://doi.org/10.1016/j.ajic.2014.02.024