Risk factors for the prediction of treatment failure in gestational trophoblastic tumors treated with EMA/CO regimen

Seung Jo Kim, Seog Nyeon Bae, Jae-Hoon Kim, Chan Joo Kim, Jae Keun Jung

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective. The purpose of this study was to determine the independent risk factors for resistance to EMA/CO chemotherapy in gestational trophoblastic tumor (GTT), to develop a more accurate scoring system for the evaluation of high-risk GTT patients. Methods. We performed a retrospective study and reviewed 165 GTT patients who received the EMA/CO regimen. Among these patients, 27 showed resistance to EMA/CO. Results. According to the univariate analysis of risk factors, tumor age, initial human chorionic gonadotropin level, metastatic site, number of metastatic organs, unplanned operation, gravidity, and inadequate previous chemotherapy all showed statistical significance. However, the results of the stepwise-Cox proportional hazards regression of prognostic factors using multivariate analysis showed statistical significance for tumor age, number of metastatic organs, metastatic site, and previously inadequate chemotherapy. The results of the stepwise logistic regression of prognostic factors showed tumor age and number of metastatic organs as significant. According to the performance of the fitted logistic regression model, the accuracy of predicted death and survival was 80.5%. Conclusions. We determined that the following factors indicate a poor prognosis: (1) tumor age greater than 12 months, (2) number of metastatic organs greater 2, (3) incomplete previous treatment, including unplanned operation and inadequate chemotherapy. In patients with two and three of these factors, the death rates were 17.7 and 56.6%, respectively.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalGynecologic Oncology
Volume71
Issue number2
DOIs
Publication statusPublished - 1998 Jan 1

Fingerprint

Trophoblastic Neoplasms
Carbon Monoxide
Treatment Failure
Drug Therapy
Logistic Models
Neoplasms
Gravidity
Chorionic Gonadotropin
Multivariate Analysis
Retrospective Studies
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Kim, Seung Jo ; Bae, Seog Nyeon ; Kim, Jae-Hoon ; Kim, Chan Joo ; Jung, Jae Keun. / Risk factors for the prediction of treatment failure in gestational trophoblastic tumors treated with EMA/CO regimen. In: Gynecologic Oncology. 1998 ; Vol. 71, No. 2. pp. 247-253.
@article{a296d9e977c4423e83d43c6452e5415a,
title = "Risk factors for the prediction of treatment failure in gestational trophoblastic tumors treated with EMA/CO regimen",
abstract = "Objective. The purpose of this study was to determine the independent risk factors for resistance to EMA/CO chemotherapy in gestational trophoblastic tumor (GTT), to develop a more accurate scoring system for the evaluation of high-risk GTT patients. Methods. We performed a retrospective study and reviewed 165 GTT patients who received the EMA/CO regimen. Among these patients, 27 showed resistance to EMA/CO. Results. According to the univariate analysis of risk factors, tumor age, initial human chorionic gonadotropin level, metastatic site, number of metastatic organs, unplanned operation, gravidity, and inadequate previous chemotherapy all showed statistical significance. However, the results of the stepwise-Cox proportional hazards regression of prognostic factors using multivariate analysis showed statistical significance for tumor age, number of metastatic organs, metastatic site, and previously inadequate chemotherapy. The results of the stepwise logistic regression of prognostic factors showed tumor age and number of metastatic organs as significant. According to the performance of the fitted logistic regression model, the accuracy of predicted death and survival was 80.5{\%}. Conclusions. We determined that the following factors indicate a poor prognosis: (1) tumor age greater than 12 months, (2) number of metastatic organs greater 2, (3) incomplete previous treatment, including unplanned operation and inadequate chemotherapy. In patients with two and three of these factors, the death rates were 17.7 and 56.6{\%}, respectively.",
author = "Kim, {Seung Jo} and Bae, {Seog Nyeon} and Jae-Hoon Kim and Kim, {Chan Joo} and Jung, {Jae Keun}",
year = "1998",
month = "1",
day = "1",
doi = "10.1006/gyno.1998.5161",
language = "English",
volume = "71",
pages = "247--253",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

Risk factors for the prediction of treatment failure in gestational trophoblastic tumors treated with EMA/CO regimen. / Kim, Seung Jo; Bae, Seog Nyeon; Kim, Jae-Hoon; Kim, Chan Joo; Jung, Jae Keun.

In: Gynecologic Oncology, Vol. 71, No. 2, 01.01.1998, p. 247-253.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for the prediction of treatment failure in gestational trophoblastic tumors treated with EMA/CO regimen

AU - Kim, Seung Jo

AU - Bae, Seog Nyeon

AU - Kim, Jae-Hoon

AU - Kim, Chan Joo

AU - Jung, Jae Keun

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Objective. The purpose of this study was to determine the independent risk factors for resistance to EMA/CO chemotherapy in gestational trophoblastic tumor (GTT), to develop a more accurate scoring system for the evaluation of high-risk GTT patients. Methods. We performed a retrospective study and reviewed 165 GTT patients who received the EMA/CO regimen. Among these patients, 27 showed resistance to EMA/CO. Results. According to the univariate analysis of risk factors, tumor age, initial human chorionic gonadotropin level, metastatic site, number of metastatic organs, unplanned operation, gravidity, and inadequate previous chemotherapy all showed statistical significance. However, the results of the stepwise-Cox proportional hazards regression of prognostic factors using multivariate analysis showed statistical significance for tumor age, number of metastatic organs, metastatic site, and previously inadequate chemotherapy. The results of the stepwise logistic regression of prognostic factors showed tumor age and number of metastatic organs as significant. According to the performance of the fitted logistic regression model, the accuracy of predicted death and survival was 80.5%. Conclusions. We determined that the following factors indicate a poor prognosis: (1) tumor age greater than 12 months, (2) number of metastatic organs greater 2, (3) incomplete previous treatment, including unplanned operation and inadequate chemotherapy. In patients with two and three of these factors, the death rates were 17.7 and 56.6%, respectively.

AB - Objective. The purpose of this study was to determine the independent risk factors for resistance to EMA/CO chemotherapy in gestational trophoblastic tumor (GTT), to develop a more accurate scoring system for the evaluation of high-risk GTT patients. Methods. We performed a retrospective study and reviewed 165 GTT patients who received the EMA/CO regimen. Among these patients, 27 showed resistance to EMA/CO. Results. According to the univariate analysis of risk factors, tumor age, initial human chorionic gonadotropin level, metastatic site, number of metastatic organs, unplanned operation, gravidity, and inadequate previous chemotherapy all showed statistical significance. However, the results of the stepwise-Cox proportional hazards regression of prognostic factors using multivariate analysis showed statistical significance for tumor age, number of metastatic organs, metastatic site, and previously inadequate chemotherapy. The results of the stepwise logistic regression of prognostic factors showed tumor age and number of metastatic organs as significant. According to the performance of the fitted logistic regression model, the accuracy of predicted death and survival was 80.5%. Conclusions. We determined that the following factors indicate a poor prognosis: (1) tumor age greater than 12 months, (2) number of metastatic organs greater 2, (3) incomplete previous treatment, including unplanned operation and inadequate chemotherapy. In patients with two and three of these factors, the death rates were 17.7 and 56.6%, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0032213033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032213033&partnerID=8YFLogxK

U2 - 10.1006/gyno.1998.5161

DO - 10.1006/gyno.1998.5161

M3 - Article

C2 - 9826467

AN - SCOPUS:0032213033

VL - 71

SP - 247

EP - 253

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -