Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea

Kyu Sik Jung, Jae Jun Park, Young Eun Chon, Eun Suk Jung, Hyun Jung Lee, Hui Won Jang, Kyong Joo Lee, Sang Hoon Lee, Chang Mo Moon, Jin Ha Lee, Jae Kook Shin, Soung Min Jeon, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background/Aims: The incidence of treatment failure or recurrence of Clostridium difficile-associated diarrhea (CDAD) following metronidazole treatment has increased recently. We studied the treatment failure, recurrence rate, and risk factors predictive of treatment failure and recurrence after metronidazole treatment for CDAD. Methods: We retrospectively identified consecutive patients who were admitted and treated for CDAD at a single tertiary institution in Korea over a recent 10-year period (i.e., 1998-2008). Results: Metronidazole was administered as the initial treatment to 111 of 117 patients (94.9%) with CDAD. Fourteen patients (12.6%) had no clinical response to the metronidazole treatment, and in 13 patients (13.4%) CDAD recurred after successful metronidazole treatment. Diabetes mellitus (p=0.014) and sepsis (p=0.002) were independent risk factors for metronidazole treatment failure. Patients who had received surgery within 1 month before CDAD developed were more likely to experience a recurrence after metronidazole treatment (p=0.032). Vancomycin exhibited a higher response rate after treatment failure, and metronidazole showed a reasonable response rate in the treatment of recurrence. Treatment failure and recurrence rates increased with time after metronidazole treatment for CDAD over the 10-year study period. Conclusions: Our data suggest that diabetes mellitus and sepsis are independent risk factors for metronidazole treatment failure, and that operation history within 1 month of development of CDAD is a predictor of a recurrence after metronidazole treatment.

Original languageEnglish
Pages (from-to)332-337
Number of pages6
JournalGut and liver
Volume4
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1

Fingerprint

Clostridium difficile
Metronidazole
Treatment Failure
Diarrhea
Recurrence
Therapeutics
Sepsis
Diabetes Mellitus
Vancomycin
Korea
History

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Jung, Kyu Sik ; Park, Jae Jun ; Chon, Young Eun ; Jung, Eun Suk ; Lee, Hyun Jung ; Jang, Hui Won ; Lee, Kyong Joo ; Lee, Sang Hoon ; Moon, Chang Mo ; Lee, Jin Ha ; Shin, Jae Kook ; Jeon, Soung Min ; Hong, Sung Pil ; Kim, Tae Il ; Kim, Won Ho ; Cheon, Jae Hee. / Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea. In: Gut and liver. 2010 ; Vol. 4, No. 3. pp. 332-337.
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abstract = "Background/Aims: The incidence of treatment failure or recurrence of Clostridium difficile-associated diarrhea (CDAD) following metronidazole treatment has increased recently. We studied the treatment failure, recurrence rate, and risk factors predictive of treatment failure and recurrence after metronidazole treatment for CDAD. Methods: We retrospectively identified consecutive patients who were admitted and treated for CDAD at a single tertiary institution in Korea over a recent 10-year period (i.e., 1998-2008). Results: Metronidazole was administered as the initial treatment to 111 of 117 patients (94.9{\%}) with CDAD. Fourteen patients (12.6{\%}) had no clinical response to the metronidazole treatment, and in 13 patients (13.4{\%}) CDAD recurred after successful metronidazole treatment. Diabetes mellitus (p=0.014) and sepsis (p=0.002) were independent risk factors for metronidazole treatment failure. Patients who had received surgery within 1 month before CDAD developed were more likely to experience a recurrence after metronidazole treatment (p=0.032). Vancomycin exhibited a higher response rate after treatment failure, and metronidazole showed a reasonable response rate in the treatment of recurrence. Treatment failure and recurrence rates increased with time after metronidazole treatment for CDAD over the 10-year study period. Conclusions: Our data suggest that diabetes mellitus and sepsis are independent risk factors for metronidazole treatment failure, and that operation history within 1 month of development of CDAD is a predictor of a recurrence after metronidazole treatment.",
author = "Jung, {Kyu Sik} and Park, {Jae Jun} and Chon, {Young Eun} and Jung, {Eun Suk} and Lee, {Hyun Jung} and Jang, {Hui Won} and Lee, {Kyong Joo} and Lee, {Sang Hoon} and Moon, {Chang Mo} and Lee, {Jin Ha} and Shin, {Jae Kook} and Jeon, {Soung Min} and Hong, {Sung Pil} and Kim, {Tae Il} and Kim, {Won Ho} and Cheon, {Jae Hee}",
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Jung, KS, Park, JJ, Chon, YE, Jung, ES, Lee, HJ, Jang, HW, Lee, KJ, Lee, SH, Moon, CM, Lee, JH, Shin, JK, Jeon, SM, Hong, SP, Kim, TI, Kim, WH & Cheon, JH 2010, 'Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea', Gut and liver, vol. 4, no. 3, pp. 332-337. https://doi.org/10.5009/gnl.2010.4.3.332

Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea. / Jung, Kyu Sik; Park, Jae Jun; Chon, Young Eun; Jung, Eun Suk; Lee, Hyun Jung; Jang, Hui Won; Lee, Kyong Joo; Lee, Sang Hoon; Moon, Chang Mo; Lee, Jin Ha; Shin, Jae Kook; Jeon, Soung Min; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, Jae Hee.

In: Gut and liver, Vol. 4, No. 3, 01.09.2010, p. 332-337.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea

AU - Jung, Kyu Sik

AU - Park, Jae Jun

AU - Chon, Young Eun

AU - Jung, Eun Suk

AU - Lee, Hyun Jung

AU - Jang, Hui Won

AU - Lee, Kyong Joo

AU - Lee, Sang Hoon

AU - Moon, Chang Mo

AU - Lee, Jin Ha

AU - Shin, Jae Kook

AU - Jeon, Soung Min

AU - Hong, Sung Pil

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Cheon, Jae Hee

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background/Aims: The incidence of treatment failure or recurrence of Clostridium difficile-associated diarrhea (CDAD) following metronidazole treatment has increased recently. We studied the treatment failure, recurrence rate, and risk factors predictive of treatment failure and recurrence after metronidazole treatment for CDAD. Methods: We retrospectively identified consecutive patients who were admitted and treated for CDAD at a single tertiary institution in Korea over a recent 10-year period (i.e., 1998-2008). Results: Metronidazole was administered as the initial treatment to 111 of 117 patients (94.9%) with CDAD. Fourteen patients (12.6%) had no clinical response to the metronidazole treatment, and in 13 patients (13.4%) CDAD recurred after successful metronidazole treatment. Diabetes mellitus (p=0.014) and sepsis (p=0.002) were independent risk factors for metronidazole treatment failure. Patients who had received surgery within 1 month before CDAD developed were more likely to experience a recurrence after metronidazole treatment (p=0.032). Vancomycin exhibited a higher response rate after treatment failure, and metronidazole showed a reasonable response rate in the treatment of recurrence. Treatment failure and recurrence rates increased with time after metronidazole treatment for CDAD over the 10-year study period. Conclusions: Our data suggest that diabetes mellitus and sepsis are independent risk factors for metronidazole treatment failure, and that operation history within 1 month of development of CDAD is a predictor of a recurrence after metronidazole treatment.

AB - Background/Aims: The incidence of treatment failure or recurrence of Clostridium difficile-associated diarrhea (CDAD) following metronidazole treatment has increased recently. We studied the treatment failure, recurrence rate, and risk factors predictive of treatment failure and recurrence after metronidazole treatment for CDAD. Methods: We retrospectively identified consecutive patients who were admitted and treated for CDAD at a single tertiary institution in Korea over a recent 10-year period (i.e., 1998-2008). Results: Metronidazole was administered as the initial treatment to 111 of 117 patients (94.9%) with CDAD. Fourteen patients (12.6%) had no clinical response to the metronidazole treatment, and in 13 patients (13.4%) CDAD recurred after successful metronidazole treatment. Diabetes mellitus (p=0.014) and sepsis (p=0.002) were independent risk factors for metronidazole treatment failure. Patients who had received surgery within 1 month before CDAD developed were more likely to experience a recurrence after metronidazole treatment (p=0.032). Vancomycin exhibited a higher response rate after treatment failure, and metronidazole showed a reasonable response rate in the treatment of recurrence. Treatment failure and recurrence rates increased with time after metronidazole treatment for CDAD over the 10-year study period. Conclusions: Our data suggest that diabetes mellitus and sepsis are independent risk factors for metronidazole treatment failure, and that operation history within 1 month of development of CDAD is a predictor of a recurrence after metronidazole treatment.

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JO - Gut and Liver

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SN - 1976-2283

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