Risk factors for tuberculosis after gastrectomy in gastric cancer

Won Jai Jung, Young Mok Park, Joo Han Song, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Hoon Noh, Ji Yeong An, Young Ae Kang

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Abstract

AIM: To examine incidence of tuberculosis (TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer. METHODS: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios (SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed. RESULTS: Among the 1776 gastrectomy patients, 0.9% (16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher than that in the general population (SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio (OR) = 7.1, P < 0.001], lower body mass index (BMI) (kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent (total gastrectomy vs subtotal gastrectomy) (OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis. CONCLUSION: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer.

Original languageEnglish
Pages (from-to)2585-2591
Number of pages7
JournalWorld Journal of Gastroenterology
Volume22
Issue number8
DOIs
Publication statusPublished - 2016 Feb 28

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Jung, W. J., Park, Y. M., Song, J. H., Chung, K. S., Kim, S. Y., Kim, E. Y., Jung, J. Y., Park, M. S., Kim, Y. S., Kim, S. K., Chang, J., Noh, S. H., An, J. Y., & Kang, Y. A. (2016). Risk factors for tuberculosis after gastrectomy in gastric cancer. World Journal of Gastroenterology, 22(8), 2585-2591. https://doi.org/10.3748/wjg.v22.i8.2585