Risk factors for visual field progression of normal-tension glaucoma in patients with myopia

Hyoung Won Bae, Sang Jin Seo, Sang Yeop Lee, Yun Ha Lee, Samin Hong, Gong Je Seong, chanyun kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. Design Longitudinal, observational study. Participants Fifty-one eyes of 51 NTG patients with myopia (less than −0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. Methods Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. Results The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11–14.92 and 1.27–15.04; p = 0.03 and 0.02, respectively). Conclusions Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalCanadian Journal of Ophthalmology
Volume52
Issue number1
DOIs
Publication statusPublished - 2017 Feb 1

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Low Tension Glaucoma
Myopia
Visual Fields
Nerve Fibers
Color
Optical Coherence Tomography
Proportional Hazards Models
Observational Studies
Longitudinal Studies
Observation

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Bae, Hyoung Won ; Seo, Sang Jin ; Lee, Sang Yeop ; Lee, Yun Ha ; Hong, Samin ; Seong, Gong Je ; kim, chanyun. / Risk factors for visual field progression of normal-tension glaucoma in patients with myopia. In: Canadian Journal of Ophthalmology. 2017 ; Vol. 52, No. 1. pp. 107-113.
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abstract = "Objective To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. Design Longitudinal, observational study. Participants Fifty-one eyes of 51 NTG patients with myopia (less than −0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. Methods Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. Results The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95{\%} CI, 1.11–14.92 and 1.27–15.04; p = 0.03 and 0.02, respectively). Conclusions Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.",
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Risk factors for visual field progression of normal-tension glaucoma in patients with myopia. / Bae, Hyoung Won; Seo, Sang Jin; Lee, Sang Yeop; Lee, Yun Ha; Hong, Samin; Seong, Gong Je; kim, chanyun.

In: Canadian Journal of Ophthalmology, Vol. 52, No. 1, 01.02.2017, p. 107-113.

Research output: Contribution to journalArticle

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AU - Seong, Gong Je

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N2 - Objective To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. Design Longitudinal, observational study. Participants Fifty-one eyes of 51 NTG patients with myopia (less than −0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. Methods Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. Results The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11–14.92 and 1.27–15.04; p = 0.03 and 0.02, respectively). Conclusions Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.

AB - Objective To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. Design Longitudinal, observational study. Participants Fifty-one eyes of 51 NTG patients with myopia (less than −0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. Methods Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. Results The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11–14.92 and 1.27–15.04; p = 0.03 and 0.02, respectively). Conclusions Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.

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