Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients

Sug Kyun Shin, Hyunjin Noh, Shin Wook Kang, Bo Jung Seo, In Hee Lee, Hyun Yong Song, Kyu Hun Choi, Sung Kyu Ha, Ho Yung Lee, Dae Suk Han

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalPeritoneal Dialysis International
Volume19
Issue number2
Publication statusPublished - 1999 Mar 1

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Continuous Ambulatory Peritoneal Dialysis
Kidney
Peritonitis
Peritoneal Dialysis
Blood Pressure
Creatinine
Urine Specimen Collection
Hematocrit
Urea
Linear Models
Diabetes Mellitus
Regression Analysis
Outcome Assessment (Health Care)
Membranes

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Shin, Sug Kyun ; Noh, Hyunjin ; Kang, Shin Wook ; Seo, Bo Jung ; Lee, In Hee ; Song, Hyun Yong ; Choi, Kyu Hun ; Ha, Sung Kyu ; Lee, Ho Yung ; Han, Dae Suk. / Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients. In: Peritoneal Dialysis International. 1999 ; Vol. 19, No. 2. pp. 138-142.
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abstract = "Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.",
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Shin, SK, Noh, H, Kang, SW, Seo, BJ, Lee, IH, Song, HY, Choi, KH, Ha, SK, Lee, HY & Han, DS 1999, 'Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients', Peritoneal Dialysis International, vol. 19, no. 2, pp. 138-142.

Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients. / Shin, Sug Kyun; Noh, Hyunjin; Kang, Shin Wook; Seo, Bo Jung; Lee, In Hee; Song, Hyun Yong; Choi, Kyu Hun; Ha, Sung Kyu; Lee, Ho Yung; Han, Dae Suk.

In: Peritoneal Dialysis International, Vol. 19, No. 2, 01.03.1999, p. 138-142.

Research output: Contribution to journalArticle

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T1 - Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients

AU - Shin, Sug Kyun

AU - Noh, Hyunjin

AU - Kang, Shin Wook

AU - Seo, Bo Jung

AU - Lee, In Hee

AU - Song, Hyun Yong

AU - Choi, Kyu Hun

AU - Ha, Sung Kyu

AU - Lee, Ho Yung

AU - Han, Dae Suk

PY - 1999/3/1

Y1 - 1999/3/1

N2 - Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.

AB - Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.

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