Abstract
Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 138-142 |
| Number of pages | 5 |
| Journal | Peritoneal Dialysis International |
| Volume | 19 |
| Issue number | 2 |
| Publication status | Published - 1999 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Nephrology
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Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients. / Shin, Sug Kyun; Noh, Hyunjin; Kang, Shin Wook; Seo, Bo Jung; Lee, In Hee; Song, Hyun Yong; Choi, Kyu Hun; Ha, Sung Kyu; Lee, Ho Yung; Han, Dae Suk.
In: Peritoneal Dialysis International, Vol. 19, No. 2, 01.03.1999, p. 138-142.Research output: Contribution to journal › Article
TY - JOUR
T1 - Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients
AU - Shin, Sug Kyun
AU - Noh, Hyunjin
AU - Kang, Shin Wook
AU - Seo, Bo Jung
AU - Lee, In Hee
AU - Song, Hyun Yong
AU - Choi, Kyu Hun
AU - Ha, Sung Kyu
AU - Lee, Ho Yung
AU - Han, Dae Suk
PY - 1999/3/1
Y1 - 1999/3/1
N2 - Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.
AB - Objective: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. Design: A retrospective single-center study. Setting: Tertiary medical center. Patients: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. Main Outcome Measures: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (C(cr)) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and C(cr) at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. Results: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). Conclusion: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033367117&partnerID=8YFLogxK
M3 - Article
C2 - 10357184
AN - SCOPUS:0033367117
VL - 19
SP - 138
EP - 142
JO - Peritoneal Dialysis International
JF - Peritoneal Dialysis International
SN - 0896-8608
IS - 2
ER -