Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients

Bum Sik Chin, Myung Soo Kim, Sang Hoon Han, So Youn Shin, Hee Kyung Choi, Yun Tae Chae, Sung Joon Jin, Ji Hyeon Baek, Jun Yong Choi, Young Goo Song, Chang Oh Kim, June Myung Kim

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Abstract

Urinary tract infection (UTI) is the most frequent cause of bacteremia/sepsis in elderly people and increasing antimicrobial resistance in uropathogens has been observed. To describe the characteristics of bacteremic UTI in elderly patients and to identify the independent risk factors of all-cause in-hospital mortality, a retrospective cohort study of bacteremic UTI patients of age over 65 was performed at a single 2000-bed tertiary hospital. Bacteremic UTI was defined as the isolation of the same organism from both urine and blood within 48 h. Eighty-six elderly bacteremic UTI patients were enrolled. Community-acquired infection was the case for most patients (79.1%), and Escherichia coli accounted for 88.6% (70/79) among Gram-negative organisms. Non- E. coli Gram-negative organisms were more frequent in hospital-acquired cases and male patients while chronic urinary catheter insertion was related with Gram-positive urosepsis. The antibiotic susceptibility among Gram-negative organisms was not different depending on the source of bacteremic UTI, while non- E. coli Gram-negative organisms were less frequently susceptible for cefotaxime, cefoperazone/sulbactam, and aztreonam. All-cause in-hospital mortality was 11.6%, and functional dependency (adjusted hazard ratio. = HR. = 10.9, 95% confidence interval. = 95%CI. = 2.2-54.6) and low serum albumin (adjusted HR. = 27.0, 95%CI. = 2.0-361.2) were independently related with increased all-cause in-hospital mortality.

Original languageEnglish
Pages (from-to)e50-e55
JournalArchives of Gerontology and Geriatrics
Volume52
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Hospital Mortality
Urinary Tract Infections
mortality
cause
Escherichia coli
Community-Acquired Infections
Aztreonam
Cefoperazone
Sulbactam
Urinary Catheters
Cefotaxime
Bacteremia
social isolation
Tertiary Care Centers
Serum Albumin
confidence
Sepsis
Cohort Studies
Retrospective Studies
Urine

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Chin, Bum Sik ; Kim, Myung Soo ; Han, Sang Hoon ; Shin, So Youn ; Choi, Hee Kyung ; Chae, Yun Tae ; Jin, Sung Joon ; Baek, Ji Hyeon ; Choi, Jun Yong ; Song, Young Goo ; Kim, Chang Oh ; Kim, June Myung. / Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients. In: Archives of Gerontology and Geriatrics. 2011 ; Vol. 52, No. 1. pp. e50-e55.
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abstract = "Urinary tract infection (UTI) is the most frequent cause of bacteremia/sepsis in elderly people and increasing antimicrobial resistance in uropathogens has been observed. To describe the characteristics of bacteremic UTI in elderly patients and to identify the independent risk factors of all-cause in-hospital mortality, a retrospective cohort study of bacteremic UTI patients of age over 65 was performed at a single 2000-bed tertiary hospital. Bacteremic UTI was defined as the isolation of the same organism from both urine and blood within 48 h. Eighty-six elderly bacteremic UTI patients were enrolled. Community-acquired infection was the case for most patients (79.1{\%}), and Escherichia coli accounted for 88.6{\%} (70/79) among Gram-negative organisms. Non- E. coli Gram-negative organisms were more frequent in hospital-acquired cases and male patients while chronic urinary catheter insertion was related with Gram-positive urosepsis. The antibiotic susceptibility among Gram-negative organisms was not different depending on the source of bacteremic UTI, while non- E. coli Gram-negative organisms were less frequently susceptible for cefotaxime, cefoperazone/sulbactam, and aztreonam. All-cause in-hospital mortality was 11.6{\%}, and functional dependency (adjusted hazard ratio. = HR. = 10.9, 95{\%} confidence interval. = 95{\%}CI. = 2.2-54.6) and low serum albumin (adjusted HR. = 27.0, 95{\%}CI. = 2.0-361.2) were independently related with increased all-cause in-hospital mortality.",
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Chin, BS, Kim, MS, Han, SH, Shin, SY, Choi, HK, Chae, YT, Jin, SJ, Baek, JH, Choi, JY, Song, YG, Kim, CO & Kim, JM 2011, 'Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients', Archives of Gerontology and Geriatrics, vol. 52, no. 1, pp. e50-e55. https://doi.org/10.1016/j.archger.2010.05.011

Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients. / Chin, Bum Sik; Kim, Myung Soo; Han, Sang Hoon; Shin, So Youn; Choi, Hee Kyung; Chae, Yun Tae; Jin, Sung Joon; Baek, Ji Hyeon; Choi, Jun Yong; Song, Young Goo; Kim, Chang Oh; Kim, June Myung.

In: Archives of Gerontology and Geriatrics, Vol. 52, No. 1, 01.01.2011, p. e50-e55.

Research output: Contribution to journalArticle

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T1 - Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients

AU - Chin, Bum Sik

AU - Kim, Myung Soo

AU - Han, Sang Hoon

AU - Shin, So Youn

AU - Choi, Hee Kyung

AU - Chae, Yun Tae

AU - Jin, Sung Joon

AU - Baek, Ji Hyeon

AU - Choi, Jun Yong

AU - Song, Young Goo

AU - Kim, Chang Oh

AU - Kim, June Myung

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