Risk factors of colistin safety according to administration routes

Intravenous and aerosolized colistin

Kyoung Lok Min, Eun Sun Son, Jae Song Kim, Soo Hyun Kim, Sun Mi Jung, Min Jung Chang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors associated with IV and AS colistin administration. Methods A retrospective study was performed in a tertiary referral hospital. Data were collected before and after colistin administration between October 2012 and April 2016. Exclusion criteria were as follows: age less than 18 years, previous colistin administration, concurrent use of IV and AS colistin, dialysis before colistin use, and colistin use for less than 3 days. We compared AKI incidence following administration of IV versus AS colistin and analyzed risk factors for colistin-associated nephrotoxicity. Results A total of 464 patients were enrolled (n = 311, IV group; n = 153, AS group). Incidence of AKI was significantly higher in the IV group (IV vs AS, 20.26% vs 7.84%, p-value < 0.001). Duration of colistin use (OR 1.033, 95% CI 1.009–1.058, p-value 0.008) and presence of chronic kidney disease (OR 2.710, 95% CI 1.348–5.448, p-value 0.005) were associated with nephrotoxicity. There were no significant risk factors associated with AS colistin. Conclusions Although AS colistin was not associated with any significant risk factors for nephrotoxicity, duration of colistin use and baseline kidney function may affect AS colistin-associated nephrotoxicity.

Original languageEnglish
Article numbere0207588
JournalPloS one
Volume13
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

colistin
Colistin
Intravenous Administration
risk factors
Safety
nephrotoxicity
Acute Kidney Injury
kidneys
incidence
Incidence
duration
Dialysis
renal function
dialysis
kidney diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Min, Kyoung Lok ; Son, Eun Sun ; Kim, Jae Song ; Kim, Soo Hyun ; Jung, Sun Mi ; Chang, Min Jung. / Risk factors of colistin safety according to administration routes : Intravenous and aerosolized colistin. In: PloS one. 2018 ; Vol. 13, No. 11.
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abstract = "Background Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors associated with IV and AS colistin administration. Methods A retrospective study was performed in a tertiary referral hospital. Data were collected before and after colistin administration between October 2012 and April 2016. Exclusion criteria were as follows: age less than 18 years, previous colistin administration, concurrent use of IV and AS colistin, dialysis before colistin use, and colistin use for less than 3 days. We compared AKI incidence following administration of IV versus AS colistin and analyzed risk factors for colistin-associated nephrotoxicity. Results A total of 464 patients were enrolled (n = 311, IV group; n = 153, AS group). Incidence of AKI was significantly higher in the IV group (IV vs AS, 20.26{\%} vs 7.84{\%}, p-value < 0.001). Duration of colistin use (OR 1.033, 95{\%} CI 1.009–1.058, p-value 0.008) and presence of chronic kidney disease (OR 2.710, 95{\%} CI 1.348–5.448, p-value 0.005) were associated with nephrotoxicity. There were no significant risk factors associated with AS colistin. Conclusions Although AS colistin was not associated with any significant risk factors for nephrotoxicity, duration of colistin use and baseline kidney function may affect AS colistin-associated nephrotoxicity.",
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Risk factors of colistin safety according to administration routes : Intravenous and aerosolized colistin. / Min, Kyoung Lok; Son, Eun Sun; Kim, Jae Song; Kim, Soo Hyun; Jung, Sun Mi; Chang, Min Jung.

In: PloS one, Vol. 13, No. 11, e0207588, 01.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk factors of colistin safety according to administration routes

T2 - Intravenous and aerosolized colistin

AU - Min, Kyoung Lok

AU - Son, Eun Sun

AU - Kim, Jae Song

AU - Kim, Soo Hyun

AU - Jung, Sun Mi

AU - Chang, Min Jung

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors associated with IV and AS colistin administration. Methods A retrospective study was performed in a tertiary referral hospital. Data were collected before and after colistin administration between October 2012 and April 2016. Exclusion criteria were as follows: age less than 18 years, previous colistin administration, concurrent use of IV and AS colistin, dialysis before colistin use, and colistin use for less than 3 days. We compared AKI incidence following administration of IV versus AS colistin and analyzed risk factors for colistin-associated nephrotoxicity. Results A total of 464 patients were enrolled (n = 311, IV group; n = 153, AS group). Incidence of AKI was significantly higher in the IV group (IV vs AS, 20.26% vs 7.84%, p-value < 0.001). Duration of colistin use (OR 1.033, 95% CI 1.009–1.058, p-value 0.008) and presence of chronic kidney disease (OR 2.710, 95% CI 1.348–5.448, p-value 0.005) were associated with nephrotoxicity. There were no significant risk factors associated with AS colistin. Conclusions Although AS colistin was not associated with any significant risk factors for nephrotoxicity, duration of colistin use and baseline kidney function may affect AS colistin-associated nephrotoxicity.

AB - Background Nephrotoxicity of intravenous (IV) colistin has impeded its clinical use; aerosolized (AS) colistin may be an alternative, but safety data are lacking. Therefore, this study aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors associated with IV and AS colistin administration. Methods A retrospective study was performed in a tertiary referral hospital. Data were collected before and after colistin administration between October 2012 and April 2016. Exclusion criteria were as follows: age less than 18 years, previous colistin administration, concurrent use of IV and AS colistin, dialysis before colistin use, and colistin use for less than 3 days. We compared AKI incidence following administration of IV versus AS colistin and analyzed risk factors for colistin-associated nephrotoxicity. Results A total of 464 patients were enrolled (n = 311, IV group; n = 153, AS group). Incidence of AKI was significantly higher in the IV group (IV vs AS, 20.26% vs 7.84%, p-value < 0.001). Duration of colistin use (OR 1.033, 95% CI 1.009–1.058, p-value 0.008) and presence of chronic kidney disease (OR 2.710, 95% CI 1.348–5.448, p-value 0.005) were associated with nephrotoxicity. There were no significant risk factors associated with AS colistin. Conclusions Although AS colistin was not associated with any significant risk factors for nephrotoxicity, duration of colistin use and baseline kidney function may affect AS colistin-associated nephrotoxicity.

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U2 - 10.1371/journal.pone.0207588

DO - 10.1371/journal.pone.0207588

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VL - 13

JO - PLoS One

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SN - 1932-6203

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