Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions

Martin C.S. Wong, Jessica Y.L. Ching, Han Mo Chiu, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D. Sollano, Furqaan Ahmed, Jayaram Menon, Siew C. Ng, Justin C.Y. Wu, Francis K.L. Chan, Joseph J.Y. Sung

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives:We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar.Methods:A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy. The prevalence of CRC, ACN, and colorectal adenoma was compared among subjects with different FDRs affected using Pearson's χ 2 tests. Binary logistic regression analyses were performed to evaluate the risk of these lesions, controlling for recognized risk factors including age, gender, smoking habits, alcohol drinking, body mass index, and the presence of diabetes mellitus.Results:Among 11,797 asymptomatic subjects, the prevalence of CRC was 0.6% (none: 0.6%; siblings: 1.1%; mother: 0.5%; father: 1.2%; ≥2 members: 3.1%, P<0.001), that of ACN was 6.5% (none: 6.1%; siblings: 8.3%; mother: 7.7%; father: 8.7%; ≥2 members: 9.3%, P<0.001), and that of colorectal adenoma was 29.3% (none: 28.6%; siblings: 33.5%; mother: 31.8%; father: 31.1%; ≥2 members: 38.1%, P<0.001). In multivariate regression analyses, subjects with at least one FDR affected were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without a family history. The risk of CRC (AOR=0.90, 95% confidence interval (CI) 0.34-2.35, P=0.830), ACN (AOR=1.07, 95% CI 0.75-1.52, P=0.714), and colorectal adenoma (AOR=0.96, 95% CI 0.78-1.19, P=0.718) in subjects with either parent affected was similar to that of subjects with their siblings affected.Conclusions:The risk of colorectal neoplasia was similar among subjects with different FDRs affected. These findings do not support the need to discriminate proband identity in screening participants with affected FDRs when their risks of colorectal neoplasia were estimated.

Original languageEnglish
Pages (from-to)1621-1629
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume111
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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Colonoscopy
Colorectal Neoplasms
Prospective Studies
Adenoma
Odds Ratio
Siblings
Neoplasms
Fathers
Mothers
Confidence Intervals
Regression Analysis
Early Detection of Cancer
Alcohol Drinking
Habits
Diabetes Mellitus
Body Mass Index
Multivariate Analysis
Logistic Models
Smoking

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Wong, Martin C.S. ; Ching, Jessica Y.L. ; Chiu, Han Mo ; Wu, Kai Chun ; Rerknimitr, Rungsun ; Li, Jingnan ; Wu, Deng Chiang ; Goh, Khean Lee ; Matsuda, Takahisa ; Kim, Hyun Soo ; Leong, Rupert ; Yeoh, Khay Guan ; Chong, Vui Heng ; Sollano, Jose D. ; Ahmed, Furqaan ; Menon, Jayaram ; Ng, Siew C. ; Wu, Justin C.Y. ; Chan, Francis K.L. ; Sung, Joseph J.Y. / Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History : A Prospective Colonoscopy Study from 16 Asia-Pacific Regions. In: American Journal of Gastroenterology. 2016 ; Vol. 111, No. 11. pp. 1621-1629.
@article{fba8f0aac8e14eb998fff5646e94fced,
title = "Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions",
abstract = "Objectives:We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar.Methods:A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy. The prevalence of CRC, ACN, and colorectal adenoma was compared among subjects with different FDRs affected using Pearson's χ 2 tests. Binary logistic regression analyses were performed to evaluate the risk of these lesions, controlling for recognized risk factors including age, gender, smoking habits, alcohol drinking, body mass index, and the presence of diabetes mellitus.Results:Among 11,797 asymptomatic subjects, the prevalence of CRC was 0.6{\%} (none: 0.6{\%}; siblings: 1.1{\%}; mother: 0.5{\%}; father: 1.2{\%}; ≥2 members: 3.1{\%}, P<0.001), that of ACN was 6.5{\%} (none: 6.1{\%}; siblings: 8.3{\%}; mother: 7.7{\%}; father: 8.7{\%}; ≥2 members: 9.3{\%}, P<0.001), and that of colorectal adenoma was 29.3{\%} (none: 28.6{\%}; siblings: 33.5{\%}; mother: 31.8{\%}; father: 31.1{\%}; ≥2 members: 38.1{\%}, P<0.001). In multivariate regression analyses, subjects with at least one FDR affected were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without a family history. The risk of CRC (AOR=0.90, 95{\%} confidence interval (CI) 0.34-2.35, P=0.830), ACN (AOR=1.07, 95{\%} CI 0.75-1.52, P=0.714), and colorectal adenoma (AOR=0.96, 95{\%} CI 0.78-1.19, P=0.718) in subjects with either parent affected was similar to that of subjects with their siblings affected.Conclusions:The risk of colorectal neoplasia was similar among subjects with different FDRs affected. These findings do not support the need to discriminate proband identity in screening participants with affected FDRs when their risks of colorectal neoplasia were estimated.",
author = "Wong, {Martin C.S.} and Ching, {Jessica Y.L.} and Chiu, {Han Mo} and Wu, {Kai Chun} and Rungsun Rerknimitr and Jingnan Li and Wu, {Deng Chiang} and Goh, {Khean Lee} and Takahisa Matsuda and Kim, {Hyun Soo} and Rupert Leong and Yeoh, {Khay Guan} and Chong, {Vui Heng} and Sollano, {Jose D.} and Furqaan Ahmed and Jayaram Menon and Ng, {Siew C.} and Wu, {Justin C.Y.} and Chan, {Francis K.L.} and Sung, {Joseph J.Y.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1038/ajg.2016.52",
language = "English",
volume = "111",
pages = "1621--1629",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "11",

}

Wong, MCS, Ching, JYL, Chiu, HM, Wu, KC, Rerknimitr, R, Li, J, Wu, DC, Goh, KL, Matsuda, T, Kim, HS, Leong, R, Yeoh, KG, Chong, VH, Sollano, JD, Ahmed, F, Menon, J, Ng, SC, Wu, JCY, Chan, FKL & Sung, JJY 2016, 'Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions', American Journal of Gastroenterology, vol. 111, no. 11, pp. 1621-1629. https://doi.org/10.1038/ajg.2016.52

Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History : A Prospective Colonoscopy Study from 16 Asia-Pacific Regions. / Wong, Martin C.S.; Ching, Jessica Y.L.; Chiu, Han Mo; Wu, Kai Chun; Rerknimitr, Rungsun; Li, Jingnan; Wu, Deng Chiang; Goh, Khean Lee; Matsuda, Takahisa; Kim, Hyun Soo; Leong, Rupert; Yeoh, Khay Guan; Chong, Vui Heng; Sollano, Jose D.; Ahmed, Furqaan; Menon, Jayaram; Ng, Siew C.; Wu, Justin C.Y.; Chan, Francis K.L.; Sung, Joseph J.Y.

In: American Journal of Gastroenterology, Vol. 111, No. 11, 01.11.2016, p. 1621-1629.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History

T2 - A Prospective Colonoscopy Study from 16 Asia-Pacific Regions

AU - Wong, Martin C.S.

AU - Ching, Jessica Y.L.

AU - Chiu, Han Mo

AU - Wu, Kai Chun

AU - Rerknimitr, Rungsun

AU - Li, Jingnan

AU - Wu, Deng Chiang

AU - Goh, Khean Lee

AU - Matsuda, Takahisa

AU - Kim, Hyun Soo

AU - Leong, Rupert

AU - Yeoh, Khay Guan

AU - Chong, Vui Heng

AU - Sollano, Jose D.

AU - Ahmed, Furqaan

AU - Menon, Jayaram

AU - Ng, Siew C.

AU - Wu, Justin C.Y.

AU - Chan, Francis K.L.

AU - Sung, Joseph J.Y.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objectives:We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar.Methods:A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy. The prevalence of CRC, ACN, and colorectal adenoma was compared among subjects with different FDRs affected using Pearson's χ 2 tests. Binary logistic regression analyses were performed to evaluate the risk of these lesions, controlling for recognized risk factors including age, gender, smoking habits, alcohol drinking, body mass index, and the presence of diabetes mellitus.Results:Among 11,797 asymptomatic subjects, the prevalence of CRC was 0.6% (none: 0.6%; siblings: 1.1%; mother: 0.5%; father: 1.2%; ≥2 members: 3.1%, P<0.001), that of ACN was 6.5% (none: 6.1%; siblings: 8.3%; mother: 7.7%; father: 8.7%; ≥2 members: 9.3%, P<0.001), and that of colorectal adenoma was 29.3% (none: 28.6%; siblings: 33.5%; mother: 31.8%; father: 31.1%; ≥2 members: 38.1%, P<0.001). In multivariate regression analyses, subjects with at least one FDR affected were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without a family history. The risk of CRC (AOR=0.90, 95% confidence interval (CI) 0.34-2.35, P=0.830), ACN (AOR=1.07, 95% CI 0.75-1.52, P=0.714), and colorectal adenoma (AOR=0.96, 95% CI 0.78-1.19, P=0.718) in subjects with either parent affected was similar to that of subjects with their siblings affected.Conclusions:The risk of colorectal neoplasia was similar among subjects with different FDRs affected. These findings do not support the need to discriminate proband identity in screening participants with affected FDRs when their risks of colorectal neoplasia were estimated.

AB - Objectives:We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar.Methods:A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy. The prevalence of CRC, ACN, and colorectal adenoma was compared among subjects with different FDRs affected using Pearson's χ 2 tests. Binary logistic regression analyses were performed to evaluate the risk of these lesions, controlling for recognized risk factors including age, gender, smoking habits, alcohol drinking, body mass index, and the presence of diabetes mellitus.Results:Among 11,797 asymptomatic subjects, the prevalence of CRC was 0.6% (none: 0.6%; siblings: 1.1%; mother: 0.5%; father: 1.2%; ≥2 members: 3.1%, P<0.001), that of ACN was 6.5% (none: 6.1%; siblings: 8.3%; mother: 7.7%; father: 8.7%; ≥2 members: 9.3%, P<0.001), and that of colorectal adenoma was 29.3% (none: 28.6%; siblings: 33.5%; mother: 31.8%; father: 31.1%; ≥2 members: 38.1%, P<0.001). In multivariate regression analyses, subjects with at least one FDR affected were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without a family history. The risk of CRC (AOR=0.90, 95% confidence interval (CI) 0.34-2.35, P=0.830), ACN (AOR=1.07, 95% CI 0.75-1.52, P=0.714), and colorectal adenoma (AOR=0.96, 95% CI 0.78-1.19, P=0.718) in subjects with either parent affected was similar to that of subjects with their siblings affected.Conclusions:The risk of colorectal neoplasia was similar among subjects with different FDRs affected. These findings do not support the need to discriminate proband identity in screening participants with affected FDRs when their risks of colorectal neoplasia were estimated.

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