Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions

Martin C.S. Wong, Jessica Y.L. Ching, Han Mo Chiu, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D. Sollano, Furqaan Ahmed, Jayaram Menon, Siew C. Ng, Justin C.Y. Wu, Francis K.L. Chan, Joseph J.Y. Sung

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Abstract

Objectives:We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar.Methods:A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy. The prevalence of CRC, ACN, and colorectal adenoma was compared among subjects with different FDRs affected using Pearson's χ 2 tests. Binary logistic regression analyses were performed to evaluate the risk of these lesions, controlling for recognized risk factors including age, gender, smoking habits, alcohol drinking, body mass index, and the presence of diabetes mellitus.Results:Among 11,797 asymptomatic subjects, the prevalence of CRC was 0.6% (none: 0.6%; siblings: 1.1%; mother: 0.5%; father: 1.2%; ≥2 members: 3.1%, P<0.001), that of ACN was 6.5% (none: 6.1%; siblings: 8.3%; mother: 7.7%; father: 8.7%; ≥2 members: 9.3%, P<0.001), and that of colorectal adenoma was 29.3% (none: 28.6%; siblings: 33.5%; mother: 31.8%; father: 31.1%; ≥2 members: 38.1%, P<0.001). In multivariate regression analyses, subjects with at least one FDR affected were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without a family history. The risk of CRC (AOR=0.90, 95% confidence interval (CI) 0.34-2.35, P=0.830), ACN (AOR=1.07, 95% CI 0.75-1.52, P=0.714), and colorectal adenoma (AOR=0.96, 95% CI 0.78-1.19, P=0.718) in subjects with either parent affected was similar to that of subjects with their siblings affected.Conclusions:The risk of colorectal neoplasia was similar among subjects with different FDRs affected. These findings do not support the need to discriminate proband identity in screening participants with affected FDRs when their risks of colorectal neoplasia were estimated.

Original languageEnglish
Pages (from-to)1621-1629
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume111
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Wong, M. C. S., Ching, J. Y. L., Chiu, H. M., Wu, K. C., Rerknimitr, R., Li, J., Wu, D. C., Goh, K. L., Matsuda, T., Kim, H. S., Leong, R., Yeoh, K. G., Chong, V. H., Sollano, J. D., Ahmed, F., Menon, J., Ng, S. C., Wu, J. C. Y., Chan, F. K. L., & Sung, J. J. Y. (2016). Risk of Colorectal Neoplasia in Individuals with Self-Reported Family History: A Prospective Colonoscopy Study from 16 Asia-Pacific Regions. American Journal of Gastroenterology, 111(11), 1621-1629. https://doi.org/10.1038/ajg.2016.52