Risk of postoperative infection in patients with inflammatory bowel disease

Hyo Suk Ahn, SangKil Lee, Hyo Jong Kim, Jae Young Jang, Kwang Ro Joo, Seok Ho Dong, Byung Ho Kim, Joung Il Lee, Young Woon Chang, Rin Chang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND/AIMS: The clinical course of patients with inflammatory bowel disease (IBD) frequently leads to the use of immunosuppressants and immunomodulators. We investigated the risk of postoperative infection in patients with IBD undergoing elective bowel surgery and whether the use of corticosteroid (CS) and/or 6-mercaptopurine/ azathioprine (6-MP/AZA) before surgery was associated with the increased risk of postoperative infection. METHODS: Patients who were diagnosed as Crohn's disease (n=25) or ulcerative colitis (n=19) and underwent elective bowel surgery between 1986 and 2005 were identified. Medical records were retrospectively analyzed including age, sex, duration of disease, indication for surgery, duration of surgery, type of surgery, type of postoperative infection, admission period, usage of CS and 6-MP/AZA, and preoperative laboratory values. There were 27 patients receiving CS alone, 6 patients receiving 6-MP/AZA alone or with CS, and 16 patients receiving neither CS nor 6-MP/AZA. RESULTS: There were 17 postoperative infections (38.6%) among IBD patients who had undergone surgery and wound infection was the most common type of infection (76.5%). In IBD patients, patients receiving CS had higher postoperative infection rate than those patients receiving neither CS nor 6-MP/AZA (p=0.039). Patients receiving CS in conjunction with 6-MP/AZA did not have significantly higher postoperative infection rate than those with CS only (p=0.415). CONCLUSIONS: Preoperative use of CS in patients with IBD is associated with the increased risk of postoperative infections. Addition of 6-MP/AZA in patients receiving CS does not increase the risk of postoperative infections.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume48
Issue number5
Publication statusPublished - 2006 Nov 1

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Inflammatory Bowel Diseases
Adrenal Cortex Hormones
6-Mercaptopurine
Azathioprine
Infection
Immunologic Factors
Wound Infection
Immunosuppressive Agents
Ulcerative Colitis
Crohn Disease
Medical Records

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ahn, H. S., Lee, S., Kim, H. J., Jang, J. Y., Joo, K. R., Dong, S. H., ... Chang, R. (2006). Risk of postoperative infection in patients with inflammatory bowel disease. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 48(5), 306-312.
Ahn, Hyo Suk ; Lee, SangKil ; Kim, Hyo Jong ; Jang, Jae Young ; Joo, Kwang Ro ; Dong, Seok Ho ; Kim, Byung Ho ; Lee, Joung Il ; Chang, Young Woon ; Chang, Rin. / Risk of postoperative infection in patients with inflammatory bowel disease. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2006 ; Vol. 48, No. 5. pp. 306-312.
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Ahn, HS, Lee, S, Kim, HJ, Jang, JY, Joo, KR, Dong, SH, Kim, BH, Lee, JI, Chang, YW & Chang, R 2006, 'Risk of postoperative infection in patients with inflammatory bowel disease', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 48, no. 5, pp. 306-312.

Risk of postoperative infection in patients with inflammatory bowel disease. / Ahn, Hyo Suk; Lee, SangKil; Kim, Hyo Jong; Jang, Jae Young; Joo, Kwang Ro; Dong, Seok Ho; Kim, Byung Ho; Lee, Joung Il; Chang, Young Woon; Chang, Rin.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 48, No. 5, 01.11.2006, p. 306-312.

Research output: Contribution to journalArticle

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AU - Ahn, Hyo Suk

AU - Lee, SangKil

AU - Kim, Hyo Jong

AU - Jang, Jae Young

AU - Joo, Kwang Ro

AU - Dong, Seok Ho

AU - Kim, Byung Ho

AU - Lee, Joung Il

AU - Chang, Young Woon

AU - Chang, Rin

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N2 - BACKGROUND/AIMS: The clinical course of patients with inflammatory bowel disease (IBD) frequently leads to the use of immunosuppressants and immunomodulators. We investigated the risk of postoperative infection in patients with IBD undergoing elective bowel surgery and whether the use of corticosteroid (CS) and/or 6-mercaptopurine/ azathioprine (6-MP/AZA) before surgery was associated with the increased risk of postoperative infection. METHODS: Patients who were diagnosed as Crohn's disease (n=25) or ulcerative colitis (n=19) and underwent elective bowel surgery between 1986 and 2005 were identified. Medical records were retrospectively analyzed including age, sex, duration of disease, indication for surgery, duration of surgery, type of surgery, type of postoperative infection, admission period, usage of CS and 6-MP/AZA, and preoperative laboratory values. There were 27 patients receiving CS alone, 6 patients receiving 6-MP/AZA alone or with CS, and 16 patients receiving neither CS nor 6-MP/AZA. RESULTS: There were 17 postoperative infections (38.6%) among IBD patients who had undergone surgery and wound infection was the most common type of infection (76.5%). In IBD patients, patients receiving CS had higher postoperative infection rate than those patients receiving neither CS nor 6-MP/AZA (p=0.039). Patients receiving CS in conjunction with 6-MP/AZA did not have significantly higher postoperative infection rate than those with CS only (p=0.415). CONCLUSIONS: Preoperative use of CS in patients with IBD is associated with the increased risk of postoperative infections. Addition of 6-MP/AZA in patients receiving CS does not increase the risk of postoperative infections.

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