Risk of psychiatric diseases among patients with psoriasis in Korea: A 12-year nationwide population-based cohort study

Jongwook Oh, Keum Ji Jung, Tae Gyun Kim, Hae Won Kim, Sun Ha Jee, Min Geol Lee

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2 Citations (Scopus)


The association between psoriasis and risk of psychiatric diseases has not been thoroughly evaluated in a large longitudinal cohort of the Asian population. We conducted a nationwide cohort study encompassing more than 1.6 million Koreans with a 12-year follow-up period. Patients were considered to be in the psoriasis cohort if they had an incident diagnostic code for psoriasis and included patients were followed up until they developed any psychiatric disease. In adjusted models, psoriasis patients (n = 10 868) were at an 18% increased risk for depression (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.09–1.26), 16% for anxiety disorders (HR, 1.16; 95% CI, 1.08–1.26), and 21% for somatoform disorders (HR, 1.21; 95% CI, 1.08–1.34) compared with the referent cohort (n = 1 620 055). Patients with moderate-to-severe psoriasis had a higher risk of developing depression and somatoform disorders than patient with mild disease (depression, HR, 1.28; 95% CI, 1.07–1.54 vs HR, 1.17; 95% CI, 1.07–1.27; somatoform disorders, HR, 1.60; 95% CI, 1.26–2.03 vs HR, 1.13; 95% CI, 1.00–1.28). Our results highlight the burden of psychiatric diseases in patients with psoriasis in Korea and suggest that appropriate medical support for possible mental illness is warranted in Asian psoriatic patients.

Original languageEnglish
Pages (from-to)1763-1771
Number of pages9
JournalJournal of Dermatology
Issue number11
Publication statusPublished - 2021 Nov

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare (HI14C2686 to S.H.J. and HI17C1659 to M.G.L.), Korea Centers for Disease Control and Prevention (2020‐ER6714‐00 to T.G.K.), a Basic Science Research Program through the National Research Foundation of Republic of Korea funded by the Ministry of Education (2016R1A6A3A11933465 to K.J.J.), and Ministry of Science and Information and Communications Technology (2019M3A9E8022135 and 2020R1C1C1014513 to T.G.K).

Publisher Copyright:
© 2021 Japanese Dermatological Association

All Science Journal Classification (ASJC) codes

  • Dermatology


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