Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients: Implications for adjuvant radiotherapy

Jee Suk Chang, Woong Sub Koom, Sang Wun Kim, Sunghoon Kim, Yong Bae Kim, Young Tae Kim, Gwi Eon Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5%) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4% of patients had a decline in CA-125 ≥90% between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0%) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1%. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55% of the overall patient population and their 5-year survival rate was 68%. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalJournal of Gynecologic Oncology
Volume24
Issue number2
DOIs
Publication statusPublished - 2013 Oct 1

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Adjuvant Radiotherapy
Gynecology
Obstetrics
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Ovarian epithelial cancer
Survival
Residual Neoplasm
Platinum
Multivariate Analysis
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

@article{89ca698395c541fbb23a16d53f90f93f,
title = "Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients: Implications for adjuvant radiotherapy",
abstract = "Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5{\%}) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4{\%} of patients had a decline in CA-125 ≥90{\%} between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0{\%}) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1{\%}. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55{\%} of the overall patient population and their 5-year survival rate was 68{\%}. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.",
author = "Chang, {Jee Suk} and Koom, {Woong Sub} and Kim, {Sang Wun} and Sunghoon Kim and Kim, {Yong Bae} and Kim, {Young Tae} and Kim, {Gwi Eon}",
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Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients : Implications for adjuvant radiotherapy. / Chang, Jee Suk; Koom, Woong Sub; Kim, Sang Wun; Kim, Sunghoon; Kim, Yong Bae; Kim, Young Tae; Kim, Gwi Eon.

In: Journal of Gynecologic Oncology, Vol. 24, No. 2, 01.10.2013, p. 146-153.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients

T2 - Implications for adjuvant radiotherapy

AU - Chang, Jee Suk

AU - Koom, Woong Sub

AU - Kim, Sang Wun

AU - Kim, Sunghoon

AU - Kim, Yong Bae

AU - Kim, Young Tae

AU - Kim, Gwi Eon

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5%) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4% of patients had a decline in CA-125 ≥90% between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0%) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1%. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55% of the overall patient population and their 5-year survival rate was 68%. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.

AB - Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were analyzed. Results: The median age of the patients was 51 years. Thirty-two patients (21.5%) were found to have residuum >2 cm after surgery. The median pretreatment CA-125 was 604 and 54.4% of patients had a decline in CA-125 ≥90% between pretreatment and at postoperative 1 month. With a median follow-up of 50 months, 79 patients (53.0%) experienced abdominopelvic failure (APF). The 5-year APF-free survival rate was 41.1%. Lymph node metastasis, size of residual disease, and decline in CA-125 were found to be significant prognostic factors for APF upon multivariate analysis. The group of patients in whom abdominopelvic irradiation was indicated as definitive postoperative treatment comprised 55% of the overall patient population and their 5-year survival rate was 68%. Conclusion: The stratification was suggested to predict APF based on lymph node metastasis, size of residual tumor, and decline in CA-125. Adjuvant radiotherapy covering the whole abdominopelvis using the intensity modulation technique may be considered to reduce APF in FIGO stage III EOC patients with intermediate risk.

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