Robust performance of deep learning for automatic detection and segmentation of brain metastases using three-dimensional black-blood and three-dimensional gradient echo imaging

Yae Won Park, Yohan Jun, Yangho Lee, Kyunghwa Han, Chansik An, Sung Soo Ahn, Dosik Hwang, Seung Koo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate whether a deep learning (DL) model using both three-dimensional (3D) black-blood (BB) imaging and 3D gradient echo (GRE) imaging may improve the detection and segmentation performance of brain metastases compared to that using only 3D GRE imaging. Methods: A total of 188 patients with brain metastases (917 lesions) who underwent a brain metastasis MRI protocol including contrast-enhanced 3D BB and 3D GRE were included in the training set. DL models based on 3D U-net were constructed. The models were validated in the test set consisting of 45 patients with brain metastases (203 lesions) and 49 patients without brain metastases. Results: The combined 3D BB and 3D GRE model yielded better performance than the 3D GRE model (sensitivities of 93.1% vs 76.8%, p < 0.001), and this effect was significantly stronger in subgroups with small metastases (p interaction < 0.001). For metastases < 3 mm, ≥ 3 mm and < 10 mm, and ≥ 10 mm, the sensitivities were 82.4%, 93.2%, and 100%, respectively. The combined 3D BB and 3D GRE model showed a false-positive per case of 0.59 in the test set. The combined 3D BB and 3D GRE model showed a Dice coefficient of 0.822, while 3D GRE model showed a lower Dice coefficient of 0.756. Conclusions: The combined 3D BB and 3D GRE DL model may improve the detection and segmentation performance of brain metastases, especially in detecting small metastases. Key Points: • The combined 3D BB and 3D GRE model yielded better performance for the detection of brain metastases than the 3D GRE model (p < 0.001), with sensitivities of 93.1% and 76.8%, respectively. • The combined 3D BB and 3D GRE model showed a false-positive rate per case of 0.59 in the test set. • The combined 3D BB and 3D GRE model showed a Dice coefficient of 0.822, while the 3D GRE model showed a lower Dice coefficient of 0.756.

Original languageEnglish
JournalEuropean Radiology
DOIs
Publication statusAccepted/In press - 2021

Bibliographical note

Funding Information:
This research received funding from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technologies & Future Planning (2020R1A2C1003886). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A1A01071648). This study was financially supported by the Faculty Research Grant of Yonsei University College of Medicine (6-2020-0149). This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2019R1A2B5B01070488), Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2018M3C7A1024734), and Y-BASE R&E Institute a Brain Korea 21, Yonsei University.

Publisher Copyright:
© 2021, European Society of Radiology.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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