Role of Agmatine in the application of neural progenitor cell in central Nervous System Diseases: Therapeutic Potentials and Effects

Renée Kosonen, Sumit Barua, Jong Youl Kim, Jong Eun Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have been discovered, demonstrating the benefits of agmatine on ischemic strokes, traumatic brain injury and numerous psychological disorders such as depression, anxiety, and stress. Agmatine also has cellular protective effects and contributes to cell proliferation and differentiation in the central nervous system (CNS). Neural progenitor cells are an important component in the recovery and repair of many neurological disorders due to their ability to differentiate into functional adult neurons. Recent data has revealed that agmatine can regulate and increase proliferation and the fate of progenitor cells in the adult hippocampus. This review aims to summarise and discuss the role of agmatine in the CNS; specifically, the effects and relationship between agmatine and neural progenitor cells and how these ideas can be applied to potential therapeutic application.

Original languageEnglish
Pages (from-to)143-151
Number of pages9
JournalAnatomy and Cell Biology
Issue number2
Publication statusPublished - 2021 Jun

Bibliographical note

Funding Information:
The author would like to thank Dr. Sumit who has since changed his position to: senior researcher, KH Medical Co. Ltd, Gyeonggi-do, Republic of Korea. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (NRF-2021R1A2C2008034).

Publisher Copyright:
Copyright © 2021. Anatomy & Cell Biology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology
  • Developmental Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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