Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer

Ki Chang Keum, Gwi Eon Kim, Chang-Ok Suh, Jong Young Lee, Jae Kyung Roh, Kwang Moon Kim, Young Ho Kim, Won Pyo Hong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Recently, neoadjuvant chemotherapy (CT) and radiation therapy (RT) have been advocated as a standard treatment for laryngeal preservation in patients with locally advanced laryngeal cancer. However, it is still being debated whether adding neoadjuvant CT to conventional RT makes an effective contribution to laryngeal preservation. The current study was designed to resolve this controversy. Design: Retrospective clinical study. Setting: The Severance Hospital, Yonsei Cancer Center, Yonsei University, Seoul, Korea. Method: Eighty patients (stages III, IV) with squamous cell carcinoma of the larynx were divided into two groups according to treatment modalities, which consisted of RT alone (N = 40, Group 1) and neoadjuvant CT plus RT (N = 40, Group 2). Comparative analysis was undertaken to investigate the differences in the organ preservation rate and treatment results between the two groups. Results: There was no significant difference in the response rate and patterns of treatment failure between the two groups. The 5-year survival rate was similar between Group 1 (24%) and Group 2 (31%) (p = .1556). In addition, the larynx was almost equally preserved in Group 1 (62%) versus Group 2 (63%). Conclusions: Radiation therapy without neoadjuvant CT seems to be a valid alternative treatment for the purpose of laryngeal preservation in locally advanced laryngeal cancer.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalJournal of Otolaryngology
Volume28
Issue number5
Publication statusPublished - 1999 Oct 1

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Laryngeal Neoplasms
Larynx
Radiotherapy
Drug Therapy
Organ Preservation
Cancer Care Facilities
Neoadjuvant Therapy
Therapeutics
Korea
Treatment Failure
Squamous Cell Carcinoma
Survival Rate
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Keum, K. C., Kim, G. E., Suh, C-O., Lee, J. Y., Roh, J. K., Kim, K. M., ... Hong, W. P. (1999). Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer. Journal of Otolaryngology, 28(5), 245-251.
Keum, Ki Chang ; Kim, Gwi Eon ; Suh, Chang-Ok ; Lee, Jong Young ; Roh, Jae Kyung ; Kim, Kwang Moon ; Kim, Young Ho ; Hong, Won Pyo. / Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer. In: Journal of Otolaryngology. 1999 ; Vol. 28, No. 5. pp. 245-251.
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abstract = "Objective: Recently, neoadjuvant chemotherapy (CT) and radiation therapy (RT) have been advocated as a standard treatment for laryngeal preservation in patients with locally advanced laryngeal cancer. However, it is still being debated whether adding neoadjuvant CT to conventional RT makes an effective contribution to laryngeal preservation. The current study was designed to resolve this controversy. Design: Retrospective clinical study. Setting: The Severance Hospital, Yonsei Cancer Center, Yonsei University, Seoul, Korea. Method: Eighty patients (stages III, IV) with squamous cell carcinoma of the larynx were divided into two groups according to treatment modalities, which consisted of RT alone (N = 40, Group 1) and neoadjuvant CT plus RT (N = 40, Group 2). Comparative analysis was undertaken to investigate the differences in the organ preservation rate and treatment results between the two groups. Results: There was no significant difference in the response rate and patterns of treatment failure between the two groups. The 5-year survival rate was similar between Group 1 (24{\%}) and Group 2 (31{\%}) (p = .1556). In addition, the larynx was almost equally preserved in Group 1 (62{\%}) versus Group 2 (63{\%}). Conclusions: Radiation therapy without neoadjuvant CT seems to be a valid alternative treatment for the purpose of laryngeal preservation in locally advanced laryngeal cancer.",
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Keum, KC, Kim, GE, Suh, C-O, Lee, JY, Roh, JK, Kim, KM, Kim, YH & Hong, WP 1999, 'Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer', Journal of Otolaryngology, vol. 28, no. 5, pp. 245-251.

Role of definitive radiation therapy for larynx preservation in patients with advanced laryngeal cancer. / Keum, Ki Chang; Kim, Gwi Eon; Suh, Chang-Ok; Lee, Jong Young; Roh, Jae Kyung; Kim, Kwang Moon; Kim, Young Ho; Hong, Won Pyo.

In: Journal of Otolaryngology, Vol. 28, No. 5, 01.10.1999, p. 245-251.

Research output: Contribution to journalArticle

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AU - Keum, Ki Chang

AU - Kim, Gwi Eon

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AU - Kim, Kwang Moon

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N2 - Objective: Recently, neoadjuvant chemotherapy (CT) and radiation therapy (RT) have been advocated as a standard treatment for laryngeal preservation in patients with locally advanced laryngeal cancer. However, it is still being debated whether adding neoadjuvant CT to conventional RT makes an effective contribution to laryngeal preservation. The current study was designed to resolve this controversy. Design: Retrospective clinical study. Setting: The Severance Hospital, Yonsei Cancer Center, Yonsei University, Seoul, Korea. Method: Eighty patients (stages III, IV) with squamous cell carcinoma of the larynx were divided into two groups according to treatment modalities, which consisted of RT alone (N = 40, Group 1) and neoadjuvant CT plus RT (N = 40, Group 2). Comparative analysis was undertaken to investigate the differences in the organ preservation rate and treatment results between the two groups. Results: There was no significant difference in the response rate and patterns of treatment failure between the two groups. The 5-year survival rate was similar between Group 1 (24%) and Group 2 (31%) (p = .1556). In addition, the larynx was almost equally preserved in Group 1 (62%) versus Group 2 (63%). Conclusions: Radiation therapy without neoadjuvant CT seems to be a valid alternative treatment for the purpose of laryngeal preservation in locally advanced laryngeal cancer.

AB - Objective: Recently, neoadjuvant chemotherapy (CT) and radiation therapy (RT) have been advocated as a standard treatment for laryngeal preservation in patients with locally advanced laryngeal cancer. However, it is still being debated whether adding neoadjuvant CT to conventional RT makes an effective contribution to laryngeal preservation. The current study was designed to resolve this controversy. Design: Retrospective clinical study. Setting: The Severance Hospital, Yonsei Cancer Center, Yonsei University, Seoul, Korea. Method: Eighty patients (stages III, IV) with squamous cell carcinoma of the larynx were divided into two groups according to treatment modalities, which consisted of RT alone (N = 40, Group 1) and neoadjuvant CT plus RT (N = 40, Group 2). Comparative analysis was undertaken to investigate the differences in the organ preservation rate and treatment results between the two groups. Results: There was no significant difference in the response rate and patterns of treatment failure between the two groups. The 5-year survival rate was similar between Group 1 (24%) and Group 2 (31%) (p = .1556). In addition, the larynx was almost equally preserved in Group 1 (62%) versus Group 2 (63%). Conclusions: Radiation therapy without neoadjuvant CT seems to be a valid alternative treatment for the purpose of laryngeal preservation in locally advanced laryngeal cancer.

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