MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1∗0301 and DQA1∗0501 were positively and DQA1∗0102 and DQA1∗0201 negatively associated with IDDM. DQB1∗0301 and DQB1∗0601 were negatively associated with IDDM. Heterodimers DQA1∗0301-DQB1∗0201, DQA1∗0501-DQB1∗0201 and DQA1∗0501-DQB1∗0302 were positively associated and DQA1∗0102-DQB1∗0601 negatively associated with IDDM. The frequencies of DR3-DQA1∗0301-DQB1∗0201 and -DQA1∗0501-DQB1∗0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1∗0301-DQB1∗0201 and DR9-DQA1∗0301-DQB1∗0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.
Bibliographical noteFunding Information:
This study was supported by a development projectg rant and faculty funds from Yonsei University, College of Medicine for 1992.W e thank Dr. G.S. Eisenbarthf or valuablec riticism.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism