Role of HLA class II alleles in Korean patients with IDDM

H. C. Lee, H. Ikegami, T. Fugisana, T. Ogihara, S. W. Park, Y. S. Chung, J. O. Park, E. J. Lee, S. K. Lim, K. R. Kim, K. B. Huh, Y. S. Kim, D. S. Lee, D. H. Kim

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Abstract

MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA10301 and DQA10501 were positively and DQA10102 and DQA10201 negatively associated with IDDM. DQB10301 and DQB10601 were negatively associated with IDDM. Heterodimers DQA10301-DQB10201, DQA10501-DQB10201 and DQA10501-DQB10302 were positively associated and DQA10102-DQB10601 negatively associated with IDDM. The frequencies of DR3-DQA10301-DQB10201 and -DQA10501-DQB10201 were significantly higher in diabetic patients. The frequencies of DR4-DQA10301-DQB10201 and DR9-DQA10301-DQB10303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume31
Issue number1-3
DOIs
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Lee, H. C., Ikegami, H., Fugisana, T., Ogihara, T., Park, S. W., Chung, Y. S., Park, J. O., Lee, E. J., Lim, S. K., Kim, K. R., Huh, K. B., Kim, Y. S., Lee, D. S., & Kim, D. H. (1996). Role of HLA class II alleles in Korean patients with IDDM. Diabetes Research and Clinical Practice, 31(1-3), 9-15. https://doi.org/10.1016/0168-8227(96)01200-4